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Breakthroughs in Brain Disease Research: Glycogen’s Role in Neurodegeneration
Researchers at the Buck Institute have uncovered that neuronal glycogen accumulation exacerbates tauopathies like Alzheimer’s disease by impairing oxidative stress management. Restoration of...
AI Advances in Antibody Discovery and Drug Modeling
A San Francisco startup supported by OpenAI launched AI models capable of designing antibodies with significantly higher lab success rates compared to existing protein models. Concurrently, Pfizer...
Thermo Fisher’s Integrated CRO-CDMO Model Slashes Oncology Development Time
According to a Tufts University study commissioned by Thermo Fisher Scientific, the company’s Accelerator solutions integrating CRO and CDMO services reduce cancer drug development timelines by up...
New Radiotheranostics and Targeted Cancer Therapies Show Progress
Actinium Pharmaceuticals presented promising data for ATNM-400, a radioconjugate targeting a non-PSMA tumor antigen in prostate cancer and other tumors, using actinium-225. Additionally, Vitsgen...
Microbiome Preservation and Environmental Biosensing Innovations
The Microbiota Vault Initiative celebrated a significant phase in its effort to ethically preserve global microbial diversity amid threats from human activities. The project outlined principles...
FDA Clears Rocket Pharmaceuticals’ Gene Therapy IND for Cardiomyopathy
The U.S. FDA has approved Rocket Pharmaceuticals’ investigational new drug application for RP-A701, a gene therapy candidate based on the AAVrh.74 vector targeting BAG3-associated dilated...
AI Transforms Antibody Discovery with New Protein Models
Chai Discovery, a San Francisco-based startup, has introduced cutting-edge AI models for de novo antibody generation that demonstrate significantly improved success rates compared to existing...
Neuronal Glycogen Breakdown Offers New Hope Against Tauopathies
Researchers from the Buck Institute and collaborators have identified how neuronal glycogen breakdown mitigates tau pathology associated with neurodegenerative diseases like Alzheimer's and...
Pliant Therapeutics Halts IPF Program Citing Safety Concerns
Pliant Therapeutics has discontinued its idiopathic pulmonary fibrosis (IPF) development program after a detailed assessment revealed an increase in adverse events in a Phase 2b/3 clinical trial...
Thermo Fisher-Tufts Study Finds Integrated CRO-CDMO Model Cuts Cancer Drug Development Nearly Three Years
A white paper by the Tufts Center for the Study of Drug Development, commissioned by Thermo Fisher Scientific, shows that their integrated Accelerator platform combining contract development and...
Genetically Modified E. coli Converts Plastic Waste Into Paracetamol
University of Edinburgh researchers have engineered Escherichia coli bacteria to convert polyethylene terephthalate (PET) plastic waste into the common painkiller paracetamol with a 92% conversion...
New Biomarkers Predict Preeclampsia and Gestational Diabetes Long Before Symptoms
Novel prenatal blood tests unveiled at the European Society of Human Reproduction and Embryology (ESHRE) reveal predictive biomarkers that identify preeclampsia and gestational diabetes mellitus...
Longevity Advocate Jim O’Neill Joins US HHS Leadership
Jim O’Neill, a noted figure in longevity research circles with ties to influencers like Bryan Johnson and Peter Thiel, has been appointed deputy secretary at the US Department of Health and Human...
Groundbreaking Immune Insights from First Pig-to-Human Kidney Transplants
An international research consortium presented novel findings at the European Society for Organ Transplantation (ESOT) 2025 on immune responses following pig-to-human kidney xenotransplantation....
AI Matches Doctors in Lung Tumor Mapping for Radiation Therapy
A recent breakthrough demonstrates that advanced AI algorithms can accurately delineate lung tumor boundaries critical for precision radiation therapy with efficacy rivalling expert oncologists....
New Study Links Gut Microbiome Imbalance to Miscarriage Risk in PCOS Women
Presented at the ESHRE annual meeting, research from Paris identifies distinct alterations of gut microbiota and amino acid metabolism associated with increased miscarriage risk in women suffering...
Plastic Waste Turned to Paracetamol Using Engineered Bacteria
Researchers at the University of Edinburgh demonstrated a novel biotechnological method to convert plastic waste into paracetamol, a widely used painkiller. By combining synthetic chemistry and...
Accelerating Oncology Drug Development via CRO-CDMO Integration
A joint study by Thermo Fisher Scientific and Tufts Center for the Study of Drug Development revealed that integrating contract development and manufacturing organizations (CDMOs) with contract...
FDA Internal Discord and Regulatory Challenges in Rare and Neuromuscular Diseases
Insider reports reveal that the FDA commissioner allegedly pushed against KalVista Pharmaceuticals’ rare disease drug approval, coinciding with the agency's investigation of Sarepta's Duchenne...
New Insights in Pig-to-Human Kidney Transplantation Immunity
An international research collaboration revealed crucial immune mechanisms following pig-to-human kidney xenotransplantation, illuminating pathways of cellular response that govern graft...