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FDA tentatively clears Lutathera generic — patent fight looms
The FDA has issued a tentative approval for Lantheus’ ANDA for PNT2003, a generic version of Novartis’ radioligand Lutathera, signaling potential competition in neuroendocrine tumor...
New HER2 ADC posts high response in bladder cancer — ASCO data
Phase 2 RC48G001 data presented at the ASCO Genitourinary Cancers Symposium show disitamab vedotin (DV), a HER2-directed antibody–drug conjugate carrying an MMAE payload, produced confirmed...
Long‑acting HIV injectables reshape monocyte immunity — study
Researchers studying people living with HIV who switched to long‑acting cabotegravir plus rilpivirine identified notable monocyte phenotype shifts and altered innate immune signaling after...
Riboflavin metabolism shields tumors from ferroptosis — Nature Cell Biology
A CRISPR–Cas9 screen published in Nature Cell Biology identified vitamin B2 (riboflavin) metabolism as a modulator of ferroptosis resistance via stabilization of FSP1 and recycling of lipid...
Vitrified mouse brains regain activity — PNAS report
A German team reported in Proceedings of the National Academy of Sciences that vitrification followed by a tailored thawing protocol preserved and restored measurable neuronal activity, metabolism...
Genetic code expansion: five noncanonical amino acids in one protein
Researchers disclosed a method enabling simultaneous incorporation of five distinct noncanonical amino acids (ncAAs) into single proteins in mammalian cells, a milestone for synthetic biology and...
SPR moves upstream: Vega platform speeds early‑stage screening
Carterra’s new Vega surface plasmon resonance (SPR) platform, described in an industry interview with chief commercial officer Tim Germann, boosts throughput to tens of thousands of interactions...
TYK2 implicated in TDP‑43 Alzheimer’s inflammation — Nature Communications
A Nature Communications study identified TYK2 as a central driver of neuroinflammation in Alzheimer’s disease cases with TDP‑43 pathology. The team showed that TYK2 signaling amplifies...
Zoledronic acid improves outcomes in Ewing sarcoma — phase III results
The EURO EWING 2012 phase III trial reported that adding zoledronic acid to standard chemotherapy improved key outcomes in patients with Ewing sarcoma, according to trial investigators. The...
Prostate screening compares to breast screening — EAU presentation
Researchers presenting at the 2026 European Association of Urology Congress argued that prostate cancer screening yields comparable benefits to breast cancer screening across detection of...
HER2 ADC Posts >50% Response in Bladder Cancer – Phase 2 RC48G001
Phase 2 RC48G001 data report that disitamab vedotin (DV), a HER2-targeted antibody–drug conjugate, produced confirmed overall response rates above 50% in both HER2-positive and HER2-low cohorts of...
FDA Gives Tentative OK to Lutathera Generic — Patent Fight Looms
The FDA issued a tentative approval for Lantheus’ PNT2003, an abbreviated new drug application aimed at replicating Novartis’ Lutathera (lutetium Lu 177 dotatate) for somatostatin...
Cadonilimab Combo Improves First-Line Outcomes in Advanced Cervical Cancer — Phase 3
COMPASSION-16 Phase 3 results showed that adding cadonilimab to chemotherapy, with and without bevacizumab, improved outcomes as first-line therapy for advanced cervical cancer. The trial reported...
Vitamin B2 Metabolism Shields Tumors from Ferroptosis — New Target Identified
A Nature Cell Biology study identified riboflavin (vitamin B2) metabolism as a modulator of ferroptosis resistance in cancer cells by stabilizing FSP1 and supporting antioxidant recycling....
Vitrification Revives Neural Activity in Mouse Brains — Cryopreservation Advance
Researchers in Germany published PNAS data demonstrating that vitrification followed by a tailored thawing protocol can preserve and partially restore neuronal firing, metabolism and plasticity in...
SPR Comes Upstream: Carterra’s Vega Brings High-Throughput Label-Free Screening
Carterra’s Vega platform expands surface plasmon resonance (SPR) throughput to enable label-free, kinetic and off-target profiling at screening scale, allowing tens of thousands of compounds per...
Five Noncanonical Amino Acids Inserted Simultaneously — Genetic Code Expansion
Researchers reported a method to incorporate five distinct noncanonical amino acids (ncAAs) into a single protein in mammalian cells, marking a major expansion of the genetic code for complex...
Federated AI Prognostic Models Developed for Anal Cancer — Multi‑Center Study
An international consortium used federated learning to develop prognostic models for anal cancer, training algorithms across multiple centers without sharing patient-level data. The Nature...
TYK2 Drives Neuroinflammation in Alzheimer’s with TDP-43 — New Therapeutic Angle
Nature Communications published evidence that TYK2 kinase activity promotes neuroinflammation in Alzheimer’s disease brains with TDP‑43 pathology. The study combined human tissue analysis,...
Monocyte Signatures Shift After Switch to Long‑Acting HIV Injectables: Immune Implications
A study analyzing people living with HIV who transitioned to long‑acting injectable cabotegravir plus rilpivirine revealed marked shifts in monocyte populations and immune activation markers. The...