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Exelixis Advances Colorectal Cancer Therapy with Phase 3 Gains
Exelixis’ experimental drug zanzalintinib combined with Roche’s checkpoint inhibitor Tecentriq demonstrated a significant overall survival improvement versus Bayer’s Stivarga in a pivotal Phase 3...
Novo Nordisk Ends Partnership with Hims Over Compounded Obesity Drugs
Novo Nordisk has terminated its marketing deal with telehealth company Hims & Hers, citing unlawful mass compounding and deceptive marketing of its obesity treatment Wegovy. The partnership,...
Breakthrough Genetic Test Predicts Chemotherapy Resistance in Cancer
Researchers at the University of Cambridge, Spanish National Cancer Research Centre (CNIO), and biotech startup Tailor Bio have developed an innovative genomic assay capable of forecasting cancer...
Advances in CAR-T Cell Therapy Address Tumor Microenvironment Challenges
Recent innovations in CAR-T therapy for lymphoma leverage engineered T cells with enhanced capabilities to overcome tumor heterogeneity, the immunosuppressive microenvironment, and T cell...
Formation Bio’s €545M Sanofi Deal Fuels JAK/SYK Inhibitor Development
AI-driven biotech Formation Bio signed a licensing agreement potentially worth €545 million with Sanofi for its dual JAK/SYK inhibitor gusacitinib. While gusacitinib is in Phase 3 for chronic hand...
Compass Pathways Reports Phase 3 Psilocybin Benefit in Depression
Compass Pathways achieved its primary endpoint in the largest phase 3 study of psilocybin for treatment-resistant depression, demonstrating a statistically significant reduction in depressive...
Leap Therapeutics Cuts 75% Workforce, Ends Sole Clinical Trial
Leap Therapeutics deepened restructuring by expanding layoffs to cover 75% of staff and terminating development of its only clinical-stage asset, sirexatamab, an anti-DKK1 antibody for cancer....
Synthetic Biology Turns Plastic Waste into Painkillers
Scientists at the University of Edinburgh engineered bacteria to convert recycled plastic waste into pharmaceutical compounds, including the widely used analgesic paracetamol. By exploiting a...
FDA Leadership Shakeup: Acting CDER Chief Exits Amid Agency Turmoil
Jacqueline Corrigan-Curay, acting director of the FDA's Center for Drug Evaluation and Research (CDER), announced her retirement effective July 2025. Her departure adds to a wave of senior staff...
Illumina's Strategic Acquisition: SomaLogic Proteomics Assets Bolster Multiomics
Illumina announced its acquisition of proteomics technology assets originally developed by SomaLogic from Standard BioTools for a deal valued up to $425 million, including upfront cash,...
Precision Genomics Partnership Targets Cardiovascular and Cancer Risk Assessment
Galatea Bio and Fabric Genomics have entered a strategic partnership to develop genetic disease risk assays integrating polygenic risk scores (PRS) with clinical gene panel interpretation....
Breakthrough Test Predicts Chemotherapy Resistance via Chromosomal Instability Signatures
Researchers at the University of Cambridge, Spanish National Cancer Research Centre, and Tailor Bio have developed a genomic test that predicts resistance to chemotherapy in diverse cancer...
Compass Pathways' Psilocybin Therapy Achieves Phase 3 Endpoint in Depression Trial
Compass Pathways reported positive outcomes from the largest-ever trial of psilocybin for treatment-resistant depression, meeting its primary endpoint of a significant reduction in depression...
Eli Lilly's Bimagrumab Enhances Fat Loss and Preserves Lean Mass with Wegovy
Data presented at the American Diabetes Association meeting showed that combining Eli Lilly's investigational drug bimagrumab with Novo Nordisk's obesity treatment Wegovy resulted in greater fat...
Closed-Loop Electrical Stimulation Stops Epileptic Seizures and Protects Memory
A novel closed-loop stimulation system was demonstrated to halt focal epilepsy progression by delivering real-time, precisely timed electrical pulses to epileptogenic brain regions upon detecting...
Advanced AI and Neural Recording Techniques Unveil Brain-Wide Primate Activity
Neuroscientists have pioneered a method enabling high-density neural recordings across the entire brain of awake nonhuman primates, integrating ultra-high-density microelectrode arrays implanted...
Reprogramming CAR T Cells In Vivo via Targeted mRNA Delivery for Cancer Therapy
Capstan Therapeutics reported data on a novel in vivo engineering approach that uses targeted lipid nanoparticles (LNPs) to deliver mRNA encoding chimeric antigen receptors (CARs) directly to...
Proteomics and Multiomics Expansion Propel Biotech Growth and Innovation
Recent corporate moves and technological advances illustrate biotechnology’s rapid expansion into proteomics and multiomics. Illumina’s acquisition of SomaLogic assets and collaborators’...
Closed-Loop Stimulation Halts Epilepsy and Safeguards Memory
Researchers have developed a novel closed-loop electrical stimulation system that interrupts focal epilepsy seizures while preserving long-term memory, as detailed in Nature Neuroscience. Unlike...
Cholinergic Neurons Mediate Brain Blood Flow and CSF Dynamics
A study published in Nature Communications reveals that basal forebrain cholinergic neurons regulate both cerebral blood flow and cerebrospinal fluid (CSF) movement. Using optogenetic activation...