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In vivo CAR-T consolidation
Eli Lilly announced it will acquire Kelonia Therapeutics for $3.25 billion upfront, as it accelerates its in vivo cell-therapy push. The deal adds a further $3.75 billion in potential clinical,...
Epilepsy regenerative medicine M&A
UCB moved to expand its epilepsy pipeline with an $1.15 billion acquisition of Neurona Therapeutics. The transaction includes a $650 million upfront payment and up to $500 million in milestone...
ADC efficacy signal in gynecologic cancers
GSK reported positive Phase I results for mocertatug rezetecan (Mo-Rez), its B7-H4 antibody-drug conjugate, in a BEHOLD-1 study spanning platinum-resistant ovarian cancer and recurrent endometrial...
MRD diagnostics deal for Foundation Medicine
Roche will expand its cancer monitoring footprint through an acquisition of MRD testing technology from SAGA Diagnostics, with Foundation Medicine set to integrate the platform. The deal is valued...
Spatial genomics instrument launch pressures competitors
10x Genomics launched Atera, a new in situ spatial biology platform designed to deliver whole-transcriptome profiling at high throughput while raising the bar on plex capacity. The instrument is...
Phase 3 win in KRAS-mutant pancreatic cancer
Revolution Medicines reported strong Phase III data for daraxonrasib (RASolute 302) in metastatic pancreatic ductal adenocarcinoma, pushing the once-undruggable KRAS space further into the...
Clinical payoff in alopecia extension
Nektar Therapeutics updated investors on extended mid-stage results for rezpeg in severe alopecia areata, describing deeper hair-growth outcomes with longer treatment. The company said after one...
Next-gen proteomics reagents for drug development
Leinco Technologies partnered with CellCarta to combine antibody portfolios for proteomics tools used in drug development and biomarker discovery. Leinco said the collaboration pairs its antibody...
Precision drug targeting: engineered resistance models
ATCC and the Broad Institute reported engineered, isogenic cancer models that replicate resistance mechanisms to targeted therapies, starting with EGFR-mutant non-small cell lung cancer treated...
Clinical supply automation for trial payments
Ledger Run upgraded its ClinRun platform to streamline how clinical trials manage payments to research sites for “invoiceables” — site costs that fall outside pre-set budgets and are often hard to...
MRD diagnostics deal
Roche struck a deal to buy Saga Diagnostics for up to $595 million, and Foundation Medicine is set to expand its molecular residual disease (MRD) offering through the acquisition of Saga’s...
MRD evidence in early breast cancer
Exact Sciences disclosed new evidence supporting its Oncodetect MRD test in early triple-negative breast cancer, presented by collaborators at AACR. The research reported an association between...
Spatial transcriptomics platform launch
10x Genomics launched Atera, an in situ spatial biology platform positioned for whole-transcriptome profiling with single-cell resolution and high throughput at AACR. The instrument is scheduled...
Drugmakers: in vivo CAR-T acquisition
Eli Lilly agreed to buy Kelonia Therapeutics for $3.25 billion upfront, underscoring its push into in vivo CAR-T. Kelonia’s lead program is in a Phase 1 study for multiple myeloma, with an...
Phase 3 readout: sickle cell oral therapy
Novo Nordisk reported Phase 3 progress for etavopivat in sickle cell disease, saying the oral drug reduced the occurrence of pain crises and improved hemoglobin response. The company also said it...
Phase 3: Nektar alopecia expansion data
Nektar Therapeutics said extended treatment with rezpeg produced greater hair growth in people with severe alopecia areata, supporting plans toward Phase 3. After one year, 27% of participants...
Oncology: KRAS inhibitor Phase 3 spotlight
Revolution Medicines’ daraxonrasib drew market attention after data from its Phase 3 RASolute 302 trial in metastatic pancreatic ductal adenocarcinoma. The available reporting described a median...
Drug discovery tools: resistant cancer model panel
ATCC and the Broad Institute reported engineered isogenic cancer models intended to accelerate study of resistance to targeted therapies. The initial platform focuses on osimertinib-resistant...
Digital/clinical supply chain operations
Almac Clinical Services released a look into how investigational drug supplies move from protocol planning through global delivery. The coverage focuses on operational controls that support...
AI and drug development speed-up bet
A Sam Altman-backed startup, as described in the coverage, is raising the stakes on using AI to shorten the path to successful clinical trials, with a $1.8 billion backing figure cited in the...