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Measles surge and ACIP upheaval... US vaccine policy in flux
Public‑health researchers reported sustained measles circulation in the U.S., with over 1,300 cases so far this year and ongoing outbreaks in multiple states, reversing two decades of elimination...
AI systems enter clinical care—trial shows benefit, security researchers raise alarms
A cluster‑randomized clinical trial published in The BMJ showed that an AI‑driven clinical decision support system improved quality of care and long‑term outcomes for acute ischemic stroke...
Scientists identify genes that let some people suppress HIV without ART
Researchers at Gladstone Institutes reported discovery of two genes that help certain individuals maintain long‑term HIV remission without daily antiretroviral therapy. The work maps molecular...
Startup pays donors for menstrual blood to build stem‑cell biobank
San Francisco startup Muse Bio began paying women to donate menstrual fluid as it builds a biobank of menstrual‑derived stem cells, aiming first at cosmetics and later at regenerative‑medicine...
Environment and bacteria reshape antimicrobial risk—unexpected exposures surface
Two studies highlighted rising antimicrobial risks from environmental contamination and bacterial defenses. Researchers documented accumulation of antibiotics in a major Brazilian river—with...
Single‑cell tools map cells to outcomes and reveal cardiac repair signals
Two teams released advances that couple single‑cell resolution with predictive and mechanistic insights. A new computational framework, scSurv, integrates bulk and single‑cell RNA sequencing to...
Molecular discoveries alter therapy landscape—ATGL, DICER reveal new levers
Two molecular studies report findings with translational implications. Researchers showed Adipose Triglyceride Lipase (ATGL) can sensitize hepatocellular carcinoma cells to chemotherapy through...
Neonatal care studies deliver actionable signals—neurobehavior links and surfactant null result
A Journal of Perinatology study linked NNNS‑II neurological profiles to pharmacologic treatment trajectories among infants exposed prenatally to opioids, providing a potential tool to stratify...
Novartis pays $2B for mutant‑selective PI3Kα pill – broadens breast cancer arsenal
Novartis agreed to buy Synnovation Therapeutics’ PI3Kα program, paying $2 billion upfront to acquire SNV4818, a mutant‑selective oral inhibitor in early clinical testing. The deal transfers rights...
AI drugmaker Earendil hauls in $787M – scales biologics pipeline
Earendil Labs closed a $787 million financing round to accelerate an AI‑driven biologics pipeline spanning autoimmune disease and oncology. Founder and CEO Jian Peng said the capital lets the...
FDA insists on sham surgery control for uniQure’s Huntington’s gene therapy
The FDA told uniQure it will require a prospective, randomized, double‑blind sham surgery‑controlled study to support a marketing application for AMT‑130, an AAV‑delivered gene‑lowering therapy...
Tumor whole‑genome sequencing shows broad clinical utility – Nature Medicine
A real‑world study published in Nature Medicine evaluated paired tumor‑normal whole‑genome sequencing (WGS) in 888 patients and found clinical utility across solid tumors. WGS succeeded in 89% of...
Engineered esophagus restores function in pig model – step toward pediatric therapy
Researchers at Great Ormond Street Hospital and UCL reported in Nature Biotechnology that an autologous, engineered esophageal segment successfully replaced a circumferential portion of esophagus...
CytomX draws $250M after varsetatug ADC data – funds expansion
CytomX completed a $250 million follow‑on offering after releasing Phase I data for its EpCAM‑targeting ADC, varsetatug masetecan (Varseta‑M), which showed a 32% objective response rate in...
Excalipoint secures $68.7M to push masked T‑cell engagers into clinic
Shanghai‑based Excalipoint raised $68.7 million in a seed round to advance three T‑cell engager platforms and a trispecific candidate now in the clinic. The company plans to develop...
AI clinical decision support improves stroke outcomes in randomized trial
A cluster‑randomized clinical trial published in The BMJ showed that an AI‑driven clinical decision support system (CDSS) improved processes of care and long‑term outcomes for patients with acute...
Utah pilots autonomous Rx refill bot — researchers flag security flaws
Utah launched a pilot to let an AI system from Doctronic autonomously process routine prescription refills to cut delays and boost adherence. A security report from Mindgard AI subsequently...
AI‑powered OCT analytics map wound healing dynamics – Duke/Nokia
Duke University engineers and Nokia Bell Labs developed an AI pipeline that analyzes optical coherence tomography (OCT) data to quantify wound healing in real time. The tool extracts structural...
Novartis pays $2 billion — buys Synnovation’s PI3Kα candidate
Novartis announced an up-front $2 billion acquisition of Pikavation Therapeutics, a Synnovation Therapeutics subsidiary, securing experimental PI3Kα inhibitor SNV4818. The deal aims to bolster...
AI biotech Earendil bags $787M — readies clinic push
Earendil Labs closed a $787 million financing to accelerate a broad pipeline of AI-designed biologics, the company said. The round included venture investors Dimension and Luminous Ventures plus...