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Capsida gene therapy trial paused after patient death
Capsida Biotherapeutics has paused enrollment in its Phase I/II Synrgy clinical trial for STXBP1 encephalopathy, a rare pediatric neurodevelopmental disorder, following the death of the first...
LB Pharmaceuticals raises $285 million in Nasdaq debut
LB Pharmaceuticals successfully completed a $285 million IPO, marking the largest biopharma offering in the U.S. since February. The company plans to advance its oral schizophrenia drug LB-102, a...
FDA approves J&J’s intravesical delivery system for bladder cancer
Johnson & Johnson received FDA approval for Inlexzo (formerly TAR-200), a drug-device combination that delivers gemcitabine directly into the bladder for patients with BCG-unresponsive, non-muscle...
CRISPR therapy shows promise in treating rare vascular disease MSMDS
Researchers at Massachusetts General Hospital engineered a bespoke CRISPR-Cas9 base editor targeting the ACTA2 gene mutation underlying multisystemic smooth muscle dysfunction syndrome (MSMDS), a...
Innovative AI-driven drug discovery and lab automation partnerships
Sapio Sciences and Ultima Genomics announced a strategic partnership integrating Sapio’s AI-powered lab informatics platform with Ultima’s high-throughput, low-cost sequencing solutions to...
Breakthroughs in cancer immunotherapy and tumor microenvironment research
New immunotherapy approaches target previously resistant tumors by harnessing innate immune pathways. A potent ENPP1 inhibitor, STF-1623, developed by Stanford and Arc Institute researchers,...
Advances in protein-targeted drug discovery using AI and novel molecular platforms
Researchers have unveiled powerful new tools and molecules to accelerate drug discovery. Harvard Medical School scientists developed PDGrapher, an AI platform that predicts combinatorial targets...
UK life science industry faces competitive challenges and policy scrutiny
The UK’s life science sector is under increasing scrutiny as major companies like Merck exit research operations citing policy and market concerns. Trade groups including the ABPI warn that UK...
Merck Halts UK Operations: Exits London $1.3B Research Lab
Merck has announced the cancellation of its plans for a $1.3 billion research laboratory in London, citing dissatisfactory progress in UK life sciences investment and policies. This move...
Novo Nordisk Restructures Amid Market Pressures: 9,000 Jobs Cut
Novo Nordisk has announced a major restructuring initiative aiming to refocus on its core diabetes and obesity markets amid heightened competition and slowing growth in obesity drugs. The Danish...
LB Pharmaceuticals Raises $285M IPO for Schizophrenia and Bipolar Drug Trials
LB Pharmaceuticals successfully completed an upsized initial public offering raising $285 million, marking the largest biotech IPO of 2025 and breaking a seven-month dry spell in biotech equity...
Innovative Gene Editing and Therapy Advances in Rare Pediatric Diseases
Recent advances in gene editing have delivered promising preclinical results in treating rare genetic disorders such as multisystemic smooth muscle dysfunction syndrome (MSMDS). Researchers at...
Small Cell Lung Cancer Forms Synaptic Connections to Neurons
Groundbreaking studies have revealed that small cell lung cancer (SCLC) cells establish functional synapses with neurons, both in the lung and in brain metastases. These synaptic connections...
AI Limitations Highlighted in Detecting Retracted Research Articles
A novel study analyzing ChatGPT’s ability to recognize retracted and problematic scientific articles revealed significant shortcomings. Researchers submitted titles and abstracts of 217 retracted...
Breakthroughs in Synthetic Biology and Drug Delivery
Innovations in drug delivery and synthetic biology continue to transform therapeutic possibilities. Researchers developed poly-L-histidine-coated mesoporous silica nanoparticles for targeted...
Regulatory and Legal Developments Impact U.S.-China Research Collaborations
The U.S. House of Representatives has passed legislation that could effectively end most academic research collaborations between the United States and China, reflecting ongoing geopolitical...
Advanced Imaging and Molecular Diagnostics in Cancer and Neuroscience
Cutting-edge imaging and molecular diagnostic techniques are advancing cancer patient management and neurodegenerative disease detection. University College London and collaborators demonstrated...
FDA Approvals and Regulatory Actions in Cancer Therapies
The U.S. Food and Drug Administration (FDA) has granted approval to Johnson & Johnson’s Inlexzo, a drug-device combination delivering intravesical gemcitabine for non-muscle invasive bladder...
Merck Exits UK Amid Industry Frustrations and £1.3B Lab Cancellation
Merck has ceased its research operations across the UK and canceled plans for a £1.3 billion ($1.31 billion) research center in London, citing insufficient government support and policy challenges...
Capsida Biotherapeutics Pauses Gene Therapy Trial After Pediatric Patient Death
Capsida Biotherapeutics has suspended its phase I/II clinical trial of CAP-002 gene therapy for STXBP1 encephalopathy following the death of the first enrolled pediatric patient. The trial, which...