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Eli Lilly in vivo CAR-T expansion via Kelonia acquisition
Eli Lilly agreed to acquire Kelonia Therapeutics in a deal worth up to $7 billion, expanding the company’s in vivo CAR-T ambitions for multiple myeloma and beyond. Lilly will pay $3.25 billion...
Updated clinical signal in alopecia areata extension study
Nektar Therapeutics disclosed additional hair-regrowth data from a 16-week extension of its Phase IIb REZOLVE-AA study of rezpegaldesleukin (rezpeg), highlighting deeper responses among late...
Whole-genome ctDNA MRD readout streamlines risk stratification in lung cancer
At AACR, researchers reported clinical value for tumor-informed MRD detection using whole-genome sequencing paired with Ultima Genomics duplex sequencing in TRACERx. The approach, using paired...
NEOPRISM-CRC bowel cancer trial reports zero relapses after short immunotherapy lead-in
A clinical trial led by University College London (UCL) and UCL Hospitals (UCLH) reported follow-up results from NEOPRISM-CRC, testing a short course of immunotherapy prior to surgery for a subset...
In vitro gene-editing map pinpoints HIV host factors in primary CD4+ T cells
Gladstone Institutes and UCSF published a genome-wide CRISPR screen mapping human genes that either promote or restrict HIV infection in primary CD4+ T cells. Using optimized infection conditions...
CRISPR-based protein activity modeling aims to improve therapeutics design
Researchers developed an AI model to predict how proteins behave by reading and learning patterns from protein pairs, targeting better representation of protein–protein interactions. The platform...
10x Genomics Atera pushes in situ whole-transcriptome spatial biology
10x Genomics launched Atera, an in situ spatial biology platform aimed at whole-transcriptome profiling with single-cell resolution and higher throughput. The company said the instrument will...
Foundation Medicine expands MRD portfolio via Roche deal for SAGA Diagnostics
Roche’s affiliate Foundation Medicine agreed to acquire SAGA Diagnostics in a transaction valued at up to $595 million, designed to broaden Foundation’s MRD diagnostics portfolio. The deal adds...
New FDA review approach for eliminating unnecessary animal studies
The FDA published a perspective on eliminating unnecessary animal studies, pushing developers toward more scientifically justified nonclinical packages and away from redundant preclinical work....
Nomic Bio and Broad Clinical Labs add quantitative proteomics to multimodal risk models
Nomic Bio partnered with Broad Clinical Labs (BCL) to integrate Nomic’s Nomic Omni 1000 immunoassay platform into BCL’s omics offerings. The collaboration is intended to incorporate quantitative...
Lilly to scale in vivo CAR-T with Kelonia buyout
Eli Lilly announced it will acquire Kelonia Therapeutics for up to $7 billion, paying $3.25 billion upfront with additional milestone payments tied to clinical, regulatory and commercial outcomes....
iGPS Kelonia purchase reframes Lilly’s in-vivo pipeline bets
Further coverage of the acquisition highlights how Kelonia’s in vivo gene placement system (iGPS) adds another clinical-stage asset to Lilly’s genetic medicines roadmap. The buyer’s broader...
CAR-T pivots to earlier disease stage in smoldering myeloma
Dana-Farber investigators reported early phase results from CAR-PRISM testing CAR-T in high-risk smoldering multiple myeloma, aiming to intercept disease before it becomes active. The dataset was...
NEOPRISM-CRC tests short immunotherapy before bowel cancer surgery
Researchers at University College London and University College London Hospitals reported follow-up results from NEOPRISM-CRC, a trial testing a short course of immunotherapy before surgery for a...
CRISPR screens map human genes that govern HIV infection in primary CD4+ T cells
Gladstone Institutes and UCSF published a genome-wide CRISPR map of host factors that either promote or restrict HIV infection in primary human CD4+ T cells. Published in Cell, the work addresses...
Watchmaker Genomics brings inhibitor-tolerant qPCR for infectious disease testing
Watchmaker Genomics showcased inhibitor-tolerant Stellar RT-qPCR and qPCR kits alongside recombinase polymerase amplification enzymes at ESCMID Global, aiming at improved robustness in infectious...
Proteomics platform expansion: Nomic Bio partners with Broad Clinical Labs
Nomic Bio announced a partnership with Broad Clinical Labs to integrate Nomic’s Nomic Omni 1000 immunoassay platform into BCL omics offerings. The collaboration is designed to embed multiplex...
Foundation Medicine’s MRD jump via Roche’s $595m SAGA acquisition
Roche’s Foundation Medicine will expand its cancer monitoring portfolio by acquiring SAGA Diagnostics for up to $595 million including milestone payments. The transaction is expected to close by...
GSK’s BEHOLD-1 Phase I ADC reports response in gynecologic cancers
GSK reported positive Phase I results from BEHOLD-1 for its B7-H4-directed antibody-drug conjugate mocertatug rezetecan (Mo-Rez) in platinum-resistant ovarian cancer and recurrent endometrial...
Novo Nordisk’s oral sickle cell drug etavopivat clears Phase 3 goals but behind timeline
Novo Nordisk reported a Phase 3 win for etavopivat, an oral therapy for sickle cell disease, aimed at reducing pain crises while improving hemoglobin response. The company said the trial met its...