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Autoantibodies Influence Cancer Immunotherapy Response
A study from Yale School of Medicine and Fred Hutchinson Cancer Center reveals that naturally occurring autoantibodies can significantly influence patient response to checkpoint immunotherapy in...
Gene Edit Stops Malaria Transmission in Mosquitoes
Researchers from UCSD and Johns Hopkins developed a CRISPR-Cas9 gene edit that introduces a naturally occurring amino acid variant into the FREP1 gene of Anopheles mosquitoes, rendering them...
FDA and Drug Development: Elevidys and Replimune Setbacks
Recent developments highlight regulatory challenges facing cutting-edge therapies. The FDA has extended its review of GSK's multiple myeloma drug Blenrep, delaying its relaunch efforts. Sarepta...
Abivax Phase 3 Data Sparks Market Surge and New Ulcerative Colitis Treatment Hopes
Abivax announced highly positive Phase 3 results for its orally available miRNA therapy obefazimod targeting moderately to severely active ulcerative colitis (UC). The pooled remission rate...
Dispatch Bio Launches with $216M to Target Solid Tumors via Novel Immunotherapy
Dispatch Bio, a new biotechnology startup specializing in immunotherapy, has emerged with $216 million in funding to develop a universal approach to treating solid tumors. The company’s Flare...
Thermo Fisher and CDMOs Report Strong Earnings Amid Market Challenges
Thermo Fisher Scientific delivered robust Q2 financial results, beating revenue and earnings expectations, prompting an 11% stock surge. Revised full-year guidance includes higher revenue and...
Genomic Advances Reveal Complex Human Variation and Epigenetic Mechanisms
Two recent studies leveraging long-read sequencing technologies provide unprecedented insights into structural variants and nearly complete human genomes from the 1000 Genomes Project. These...
Sanofi Acquires Vicebio to Expand Non-mRNA Respiratory Vaccine Portfolio
Sanofi announced a strategic acquisition of London-based biotech Vicebio for $1.15 billion upfront plus up to $450 million in milestones. Vicebio's lead candidate, VXB-241, a bivalent vaccine...
AI and Machine Learning Propel Innovations in Drug Discovery and Bioprocessing
Advancements in AI are accelerating biotechnology, exemplified by Jura Bio's VISTA platform for large-scale de novo antibody design using AI-driven data loops combined with experimental...
Neuroscience Insights: Gut-Brain Communication and Neurovascular Imaging
Recent studies deepen understanding of neurobiological processes. Duke University researchers identified a gut-brain communication mechanism where colonic neuropods detect bacterial flagellin...
Leadership Changes and Corporate Reshaping in Biotech Sector
Several biopharma and med-tech firms announced significant leadership appointments, restructurings, and workforce adjustments. Korro Bio, despite cutting 20% of staff, reaffirmed its clinical...
Novel Genetic Approaches to Disease Control and Biodiversity Conservation
Innovations in gene editing offer transformative potential across health and environment. An international team used CRISPR to introduce a naturally occurring allele into Anopheles stephensi...
Thermo Fisher Raises 2025 Outlook After Strong Q2 Results
Thermo Fisher Scientific reported better-than-expected Q2 earnings, with revenues up 3% year-over-year to $10.86 billion, driven by growth in life sciences and biopharma services. The company...
Sanofi Acquires Vicebio to Expand Respiratory Vaccine Portfolio
French pharma Sanofi agreed to acquire UK-based vaccine firm Vicebio for $1.15 billion upfront, with potential milestone payments of $450 million. Vicebio’s lead candidate, VXB-241, is a bivalent...
FDA Rejects Replimune’s Oncolytic Virus Therapy for Melanoma
The FDA issued a complete response letter rejecting Replimune’s RP1 oncolytic virus therapy for advanced melanoma. The agency cited inadequate and uncontrolled clinical investigation and concerns...
Abivax’s Ulcerative Colitis Drug Shows Positive Phase 3 Data, Shares Soar
French biotech Abivax announced positive phase 3 results for obefazimod, its orally available miRNA-124 enhancer for ulcerative colitis, achieving a 16.4% placebo-adjusted clinical remission at...
Dispatch Bio Launches with $216M to Target Solid Tumors Using Novel Immunotherapy
Dispatch Bio debuted its platform delivering a viral vector carrying a universal antigen called Flare that tags solid tumor cells, enabling immune system recognition and clearance without damaging...
CRISPR Edit in Mosquito Gene FREP1 Blocks Malaria Transmission
Researchers at UC San Diego and Johns Hopkins used CRISPR-Cas9 to introduce a naturally occurring variant in the mosquito FREP1 gene that makes mosquitoes refractory to malaria infection. This...
Long-Read Sequencing Enhances Human Genome Structural Variant Maps
Two international research teams applied long-read sequencing to over 1,000 genomes from diverse populations, providing unprecedented detail on structural variants (SVs) including insertions,...
Advancements in Biomanufacturing: Media Optimization and Inline Buffer Preparation
Researchers at Johns Hopkins developed a hybrid machine-learning and thermodynamic modeling system to optimize cell culture media formulations for biotherapeutic production, enhancing data...