Latest Biotech News

Novo Nordisk moved to stop two additional late-stage cardiovascular trials of ziltivekimab, citing a data monitoring committee determination that the studies were unlikely to succeed. The pullback...

Superluminal Medicines raised an oversubscribed $60 million Series B to advance its AI-powered GPCR platform and initiate a Phase I trial by year-end. The company’s lead asset is a selective,...

Rezubio Pharmaceuticals advanced RZ-520 for chronic respiratory diseases into Phase I after IND clearances from the FDA and China’s NMPA. The program is moving into dosing for a Phase I trial in...

Acepodia obtained FDA IND clearance for ACE-723, a GPC3-targeted dual-payload antibody-drug conjugate. The company plans to begin a Phase I trial in patients with unresectable or metastatic...

Researchers at UC San Francisco proposed a personalized antitumor vaccine built by combining expandable, genetically modifiable hiPSCs with “tumor-membrane dressing” to display tumor-derived...

Shanghai Jiao Tong University characterized BsNb PX4, an anti-PD-L1/CXCR4 bispecific nanobody, and tested its antitumor activity in triple-negative breast cancer models. Using imaging and...

Oncopia Therapeutics disclosed new patent-protected PROTAC designs targeting PRMT5, a protein arginine N-methyltransferase implicated in cancer biology. The platform pairs an E3 ubiquitin...

Researchers from the San Raffaele Telethon Institute for Gene Therapy assessed a liver-directed lentiviral vector gene therapy in a mouse model of methylmalonic acidemia and in patient-derived...

Researchers at Ohio State University reported that a fully digital, patient-driven alternative to traditional genetic counseling improves cancer genetics knowledge for people at high risk for...

NewBiologix and Synastra Biotechnology announced a manufacturing agreement to advance rAAV production for Synastra’s investigational Duchenne muscular dystrophy (DMD) gene therapy program. The...

Novo Nordisk moved to stop two additional late-stage studies of the IL-6 inhibitor ziltivekimab after a data monitoring committee concluded the trials were unlikely to meet success criteria. The...

Researchers reported that a bacterial metabolite detected in patients colonized with carbapenem-resistant Klebsiella pneumoniae can weaken CD19 CAR-T cell activity in vitro. In a Cancer...

An international team used multi-omics to connect the gut microbiome to atherosclerosis biology by identifying a pathway involving SYNPO2/VNN1 and proposing a microbiota-based vaccine angle. The...

A research team from The Second Qilu Hospital of Shandong University described a microfluidic method to boost CAR T cell transduction under low viral doses. The approach aims to shorten the...

A new systematic review in the International Journal of Legal Medicine assessed genetic autopsy findings for unexplained sudden cardiac deaths. The work focuses on cases where standard evaluation...

Researchers in the Journal of Molecular Medicine questioned the scientific performance of the FDA-cleared Lumipulse G plasma ratio for Alzheimer’s disease screening. The review argues the...

A study in BMC Medical Imaging introduced a radiomics-and-AI approach to predict the grade of multicenter kidney cancer using multi-phase CT data. By extracting quantitative imaging features...

Case Western Reserve University researchers described a mechanistic roadmap for multivalent mRNA-exosome vaccines designed to convert immunologically “cold” tumors into inflamed “hot” ones. The...

A Nature Biotechnology report detailed how six proteomic clocks were integrated into a phase 2a clinical trial to support simultaneous geroprotective assessment. The design reflects an expanded...

Novo Nordisk has ended two additional late-stage studies of ziltivekimab, its IL-6 inhibitor, after a data monitoring committee concluded the trials were unlikely to succeed. The early termination...