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CMS unveils Medicare GLP-1 payment model: voluntary pilot to expand access
CMS launched a voluntary Medicare payment model designed to broaden coverage of GLP‑1 therapies for weight loss and diabetes. The agency framed the pilot as a mechanism to lower beneficiary...
FDA approves Yartemlea: first drug for deadly stem‑cell transplant complication
The FDA granted approval to Omeros’s complement inhibitor Yartemlea as the first therapy for a severe, potentially fatal complication arising after hematopoietic stem‑cell transplantation. The...
SpatialBench... a real‑world benchmark to stress‑test biology AI agents
Researchers introduced SpatialBench, a suite of 146 verifiable problems drawn from authentic spatial biology workflows to benchmark AI agents on real analysis tasks. The dataset spans five...
Tumor‑responsive AAVs: engineered vectors that sense the microenvironment
A research team disclosed an intelligent design framework for adeno‑associated virus (AAV) vectors that selectively activate within the tumor microenvironment (TME). The engineered AAVs...
Nanovaccines target HCC: nanotechnology-based immunotherapy advances
Researchers reported nanovaccine platforms designed to stimulate anti‑tumor immunity against hepatocellular carcinoma (HCC). The nanovaccines package tumor antigens and adjuvants into nanoparticle...
Dual IGF‑1R and autophagy blockade halts metastasis: a combinatorial strategy
A 2026 study demonstrated that simultaneous inhibition of IGF‑1 receptor signaling and autophagy suppresses colorectal cancer metastasis in preclinical models. Mahgoub and colleagues showed the...
Targeted protein degradation... mapping cross‑species and health consequences
A multidisciplinary review examined the accelerating field of targeted protein degradation and its broader implications for health, ecology and species biology. The authors mapped how modalities...
CAR‑T neurotoxicity: new clinical insights and mitigation strategies
Recent analyses have deepened understanding of neurotoxic events associated with CAR‑T cell therapies and outlined approaches to reduce incidence and severity. Investigators reviewed clinical...
Mid‑stage drug flops... J&J, Biohaven cut losses after clinical failures
Two mid‑stage program failures landed this week: Johnson & Johnson announced it discontinued an eczema candidate acquired for $1.25 billion after it failed to meet efficacy thresholds, while...
Exosomal lncRNAs drive tumor signaling in head, neck and thyroid cancers
A study detailed how exosome‑associated long non‑coding RNAs (lncRNAs) modulate tumor behavior across head, neck and thyroid cancers, identifying specific extracellular RNA signatures that...
CMS unveils Medicare model for GLP‑1s: voluntary pilot to expand access
CMS launched a voluntary Medicare payment model designed to expand coverage for GLP‑1 weight‑loss drugs. The agency framed the program as a pilot to test payment and access pathways for expensive...
FDA greenlights Yartemlea — first approved therapy for fatal post‑transplant complication
The FDA approved Omeros’s complement inhibitor Yartemlea to treat a life‑threatening complication of hematopoietic stem cell transplants. This is the first regulatory approval for the indication,...
Big pharma pipeline wobble: J&J scraps eczema asset; Biohaven drug fails mid‑stage
Johnson & Johnson terminated development of an experimental eczema drug it acquired for $1.25 billion after the asset failed to meet internal efficacy thresholds. Separately, Biohaven reported a...
Study maps CAR‑T neurotoxicity mechanisms — new safety insights
Researchers published new findings that deepen understanding of neurotoxic effects associated with CAR‑T cell therapies. The work dissects mechanistic drivers of neurotoxicity and identifies...
Engineered AAVs sense tumors — a new vector design for precision delivery
A research team unveiled an intelligent design framework for adeno‑associated virus (AAV) vectors that dynamically respond to tumor microenvironment cues to improve targeting and intratumoral...
Nanovaccines retool HCC immunotherapy: preclinical advances
Researchers reported progress in nanovaccine platforms designed to stimulate antitumor immunity against hepatocellular carcinoma (HCC). The study details nanoparticle formulations that deliver...
Targeted protein degradation expands — study flags cross‑species and health impacts
A new analysis examined biological and ecological implications of targeted protein degradation technologies as they move toward therapeutic and research use. The work synthesizes evidence that...
Muse cells reduce neurodegeneration in Parkinson’s models
A translational study reported that muse cells, a class of pluripotent stem cells found in adult tissues, reduced neurodegeneration in Parkinson’s disease models. The investigators documented...
SpatialBench: benchmark exposes agents’ gaps on real spatial biology tasks
SpatialBench, a new benchmark suite, evaluates agent‑based tools on realistic spatial biology analysis workflows and reveals performance gaps between demo scenarios and deployment‑grade tasks. The...
Microbiota signature links breast, colorectal and lung cancers
A multicancer study mapped tumor‑associated microbiota and found overlapping microbial signatures across breast, colorectal and lung cancers. The multidisciplinary team reported conserved taxa and...