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Skyhawk Therapeutics and Merck KGaA Ink $2B Neurological RNA Drug Deal
Skyhawk Therapeutics entered a neurology-focused collaboration with Merck KGaA, potentially worth over $2 billion, targeting RNA splicing modulation for difficult-to-treat neurological diseases....
Gene Therapy Biotech Kriya Therapeutics Raises $313 Million
Kriya Therapeutics secured $313 million in a new funding round, making it one of the largest private biotech fundraises this year. The company develops gene therapies across neurology, metabolic...
Stealth BioTherapeutics Resubmits Rare Disease Drug to FDA After Rejection
Stealth BioTherapeutics has resubmitted its drug application for an ultra-rare Barth syndrome therapy following an FDA rejection earlier this year. The company has struggled to align with the...
Promising Cancer Immunotherapy Advances: Tislelizumab and TCR T-Cell Therapy
New data from clinical trials highlight breakthroughs in immunotherapy for hard-to-treat cancers. The phase 2 TD-NICE trial shows favorable four-year outcomes combining tislelizumab with...
Artificial Intelligence Accelerates RNA Delivery Nanoparticle Design
MIT researchers developed Composite Material Transformer (COMET), an AI-powered machine learning model, optimizing lipid nanoparticle (LNP) formulations for RNA delivery. COMET predicts efficient...
Advances in Protein Language Models Unlock Biological Mechanisms
Recent research at MIT and Cambridge has illuminated how large language models (LLMs) trained on protein sequence data can predict structure and function, deepening our understanding of protein...
Aircraft Wastewater Surveillance Emerges as Weapon Against Global Superbugs
Australian CSIRO scientists, collaborating internationally, have proposed a novel public health surveillance system utilizing aircraft wastewater to monitor antimicrobial resistance (AMR)...
Stem Cell Method Sparks Meiosis for Infertility Solutions
Harvard’s Wyss Institute pioneered a stem cell differentiation technique that directly induces meiosis from human iPSCs, bypassing intermediate stages, fostering the generation of gametes in...
US Cuts to mRNA Vaccine Funding Spark Pandemic Preparedness Concerns
The U.S. Department of Health and Human Services' decision to reduce funding for mRNA vaccine research has drawn criticism from the scientific community. Experts warn that this cut could weaken...
Anocca Raises $46M to Advance KRAS-Targeted Pancreatic Cancer Therapy
Swedish biotech firm Anocca secured $46 million to support clinical development of VIDAR-1, a nonviral genome-edited T-cell receptor (TCR) T-cell therapy targeting mutant KRAS in pancreatic ductal...
Genentech Ends Cell Therapy Collaboration with Adaptive Biotechnologies
Roche’s Genentech has terminated its multi-year collaboration with Adaptive Biotechnologies on cancer cell therapy development, ending a partnership valued at up to $2 billion. The alliance...
Novo Nordisk’s Wegovy Receives FDA Nod for Metabolic Liver Disease
The FDA granted accelerated approval to Novo Nordisk’s Wegovy for adults with metabolic dysfunction-associated steatohepatitis (MASH) featuring moderate-to-advanced liver fibrosis. This marks...
Reunion Neuroscience’s Psychedelic Drug Advances in Postpartum Depression
Reunion Neuroscience reported successful Phase 2 results for its short-acting psychedelic candidate RE104 in treating postpartum depression. The drug, functionally similar to psilocybin,...
Skyhawk and Merck KGaA Ink $2 Billion RNA Neurological Pact
RNA-targeting biotech Skyhawk Therapeutics entered a collaboration with Merck KGaA focused on neurological diseases, potentially worth $2 billion. Utilizing Skyhawk’s RNA splicing platform...
Stealth BioTherapeutics Pursues FDA Approval Amid Rare Disease Challenges
Stealth BioTherapeutics has resubmitted a new drug application for its Barth syndrome treatment following an FDA rejection. The company faces regulatory hurdles in generating sufficient data for...
Advanced AI-Designed Nanoparticles Propel Next-Gen RNA Therapies
Researchers at MIT unveiled a novel AI-driven approach to design lipid nanoparticles (LNPs) that enhance RNA vaccine and therapeutic delivery. The Composite Material Transformer (COMET) machine...
New Insights Into Treatment Resistance and Molecular Targets in Cancer
Multiple studies have illuminated mechanisms contributing to cancer treatment resistance and progression. Research from Garvan Institute identified suppression of JNK pathway driving estrogen...
Immunotherapy Advances in Lung Cancer with Liver Metastases
A recent systematic review and network meta-analysis evaluate immune checkpoint inhibitor (ICI) combinations for driver gene-negative non-small cell lung cancer patients presenting with liver...
Adaptive Biotechnologies, Genentech End Cancer Cell Therapy Pact
Adaptive Biotechnologies and Genentech will conclude their nearly six-and-a-half-year collaboration to develop personalized cancer cell therapies. The partnership used Adaptive’s T cell receptor...
Novo Nordisk’s Wegovy Clears FDA for Fatty Liver Disease
Novo Nordisk’s weight loss drug Wegovy received accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), a prevalent liver condition. Phase 3 trials...