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Tumor immunity rewired: complement genes and TBK1/IKKε inhibition
Two mechanistic oncology studies mapped complementary ways to reshape tumor immunity. A Nature Communications paper dissected how germline and somatic variation in complement cascade genes...
FDA’s biosimilar push hits patent office
U.S. regulators announced a plan to streamline approval of biosimilars to make copycat biologics cheaper and faster to market, but industry officials warn the U.S. Patent and Trademark Office is...
ACE2 decoy receptor... Blocks mutant SARS-CoV-2
Researchers led by Lin et al. reported an engineered ACE2 decoy receptor that neutralizes multiple SARS-CoV-2 variants in vitro, including escape mutants. The work, published in the Journal of...
CRISPR assay detects BK and JC viruses in transplant patients
A CRISPR-based diagnostic developed by Liu, Xu, and Cao rapidly detects BK and JC viruses in post-kidney-transplant patients, improving surveillance timelines for polyomavirus reactivation. The...
Ferroptosis drives sepsis — IgG levels predict outcomes
New mechanistic work links ferroptosis, an iron-dependent form of cell death, to sepsis pathogenesis and organ dysfunction. The study maps lipid peroxidation and iron-handling pathways activated...
Sibiriline: first dual inhibitor of necroptosis and ferroptosis
Researchers disclosed Sibiriline, a small molecule that simultaneously inhibits necroptosis and ferroptosis in preclinical models. The compound blocks key effectors in both cell-death pathways and...
Cathepsin L dual hit... Targets tumor growth and muscle wasting
A Nature Communications study identifies Cathepsin L as a shared driver of tumor progression and cancer-associated muscle wasting. Investigators used genetic and pharmacologic inhibition to show...
Mirikizumab: single 2-ml injection bioequivalent to two 1-ml shots
A pharmacokinetic study led by Otani, Payne, and Loftus reported that a single 2‑ml subcutaneous injection of mirikizumab is bioequivalent to two separate 1‑ml injections in healthy volunteers....
mTORC1 in ILC2s... Links neurons to allergic lung inflammation
Wang, Hu, Chen and colleagues published in Nature Communications that mTORC1 signaling within group 2 innate lymphoid cells (ILC2s) mediates neuro-immune cross-talk driving allergic lung...
Complement genes: alter pancreatic cancer susceptibility and outcomes
A Nature Communications analysis dissected germline and somatic variation in complement system genes and linked them to pancreatic cancer risk, tumor microenvironment changes, and patient...
Ultrasound-triggered PANoptosis: piezoelectric nanocatalysts induce tumor death
Xu et al. reported an ultrasound-activated therapy using piezoelectric nanocatalysts that triggers PANoptosis—a combined inflammatory cell-death program—in tumor models. The approach uses focused...
FDA biosimilar plan: patent office rules threaten rollout
The FDA announced a proposal to regulate biosimilars more like small-molecule generics, aiming to halve development time and lower costs substantially. Industry leaders including Stefan Glombitza...
CRISPR test detects BK and JC viruses after kidney transplant
Researchers led by Liu, Y., Xu JS., and Cao L. developed a CRISPR-based assay to detect BK and JC polyomaviruses in kidney-transplant recipients. The team validated the assay’s specificity and...
Sibiriline: single compound blocks necroptosis and ferroptosis
Scientists reported discovery of Sibiriline, a small-molecule inhibitor that simultaneously blocks necroptosis and ferroptosis—two regulated cell‑death pathways implicated in degenerative and...
Anti‑PD‑1 plus chemotherapy rewires early hormone‑positive breast tumors
A new clinical-translational study found that combining anti‑PD‑1 immunotherapy with chemotherapy induces profound cellular reprogramming in early-stage, hormone-receptor–positive (HR+) breast...
Complement‑system genes linked to pancreatic cancer risk and outcomes
A Nature Communications study mapped genetic variation across complement cascade genes and found associations with pancreatic cancer susceptibility and prognosis. The multi-omic analysis...
Beyond BRCA: genomic evolution mapped in high‑grade serous ovarian cancer
A genomic study led by Pokorna, Orlickova, Machackova and colleagues reconstructed evolutionary trajectories in high‑grade serous ovarian cancer (HGSOC) beyond canonical BRCA alterations. By...
Human genetics tie gut microbiota to bone mass
A Nature Communications study combined human genetic data and microbiome profiling to demonstrate a causal link between gut microbial composition and bone mass regulation. Using genome-wide...
Genome graphs reveal structural variation driving TB evolution
Researchers applied genome-graph methods to Mycobacterium tuberculosis and uncovered large structural variants that traditional reference-based analyses miss. The Nature Communications paper shows...
Ultrasound plus piezoelectric nanocatalysts induces tumor PANoptosis
Xu and colleagues published a preclinical report in Military Medicine Research describing a tumor-catalytic PANoptosis approach: ultrasound-activated piezoelectric nanocatalysts trigger...