Get the Daily Brief
Latest Biotech News
FDA approval and gene-therapy milestone
Rocket Pharmaceuticals said the FDA approved its gene therapy Kresladi (marnetegragene autotemcel) for leukocyte adhesion deficiency type I, and the program earned a rare pediatric disease...
Biopharma data platforms and discovery collaboration
TriNetX will link its large de-identified health database with Regeneron for genomic and proteomic data access under an exclusive, secure, licensed arrangement covering roughly 300 million...
Clinical genomics and multi-omics instrumentation rollout
Caris Life Sciences launched Caris ChromoSeq, a combined whole-genome sequencing and whole-transcriptome assay aimed at improving clinical genomic evaluation for myeloid malignancies. The test...
MCED oncology diagnostics trial scrutiny
Clinicians offering early access to Grail’s multi-cancer early detection (MCED) test are waiting for a full NHS trial readout after an endpoint miss, according to reporting. The situation is...
Oncology supportive care: EGFR-mutant NSCLC skin toxicity reduction
Interim results from the phase II COCOON trial showed a 50% reduction in dermatologic toxicities when proactive skincare was used in frontline EGFR-mutant non-small cell lung cancer patients. The...
Epigenetic reactivation strategy in acute myeloid leukemia
Researchers at The Jackson Laboratory (JAX) reported an epigenetic approach that reactivates a tumor suppressor gene in acute myeloid leukemia models. In mouse experiments published in Science...
Hematology: post-ibrutinib transplant outcomes and risks
A new analysis examines clinical outcomes and risks following transplantation in patients with relapsed or refractory mantle cell lymphoma after ibrutinib exposure. The focus is on how targeted...
Obesity–immunology link in type 2 diabetes
Researchers reported evidence connecting obesity with functional exhaustion of circulating γδ T cells in individuals with type 2 diabetes, tying metabolic disease severity to changes in an...
Regenerative/investigational delivery: hemostatic microgels for neonatal surgery
Biomedical engineers from the University of North Carolina at Chapel Hill and North Carolina State University reported development of an injectable hemostatic microgel to reduce bleeding in...
Business and policy: EU biotech competitiveness effort
Industry stakeholders discussed the proposed EU Biotech Act as a lever to improve European biotech competitiveness, with emphasis on manufacturing supply chains and harmonized pathways to market....
FDA gene therapy approval and pediatric priority review voucher
FDA approved Rocket Pharmaceuticals’ gene therapy Kresladi (marnetegragene autotemcel) for leukocyte adhesion deficiency type I, the company said, making it one of the March approvals that earned...
Data partnership for large-scale genomic and proteomic access
TriNetX and Regeneron announced an agreement linking genomic and proteomic data for drug discovery and development, with TriNetX providing Regeneron exclusive, secure access to de-identified...
Phase 2 supportive care approach in EGFR-mutant NSCLC
Interim results from the phase II COCOON trial showed that proactive skincare reduced dermatologic toxicity by 50% in patients receiving frontline treatment for EGFR-mutant non-small cell lung...
Programmable cell therapy and oncology tech from Caris and Parse
Caris Life Sciences launched Caris ChromoSeq, a combined whole-genome sequencing and whole-transcriptome assay intended to improve comprehensive genomic evaluation of myeloid malignancies. The...
Targeted oncology biology: antiprogestin resistance and SCLC molecular profiling
Researchers reported in the British Journal of Cancer that targetable molecular markers help define antiprogestin-resistant breast cancer, particularly in luminal disease where endocrine...
Immuno-oncology mechanism: glycocholic acid modulates checkpoint therapy efficacy
A new study reported by researchers on circulating glycocholic acid (GCA) links bile-acid biology to the performance of immune checkpoint therapy in colorectal cancer. The work suggests GCA can...
Hemostasis in neonates: injectable microgel reduces surgery bleeding in animals
Biomedical engineers at the University of North Carolina at Chapel Hill and North Carolina State University developed an injectable hemostatic microgel designed for neonatal-specific clotting,...
AML epigenetic reactivation strategy using KDM4 inhibition
Researchers from The Jackson Laboratory and collaborators reported an epigenetic approach that restores a tumor suppressor in acute myeloid leukemia by inhibiting KDM4 enzymes. The work, published...
Microfluidics and multi-omics platform expansion
SeekGene said it is expanding internationally with multi-omics offerings built on its SeekOne Digital Droplet microfluidics platform, targeting Europe as a first priority and planning later...
Gene drive constraints in agriculture: seed dormancy as a deployment limiter
A plant biotech study highlighted seed dormancy as a factor that could change how gene drives perform in real-world settings. Researchers reported that dormancy dynamics can influence the timing...