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Appeals court remands Guardant case — Guardant360 CDx wins FDA approval
Two legal and regulatory developments touched Guardant Health this week. The US Court of Appeals remanded a patent‑infringement dispute between Guardant, TwinStrand Biosciences and the University...
Corcept posts survival win — relacorilant reads as FDA‑fileable
Corcept Therapeutics reported a Phase III Rosella trial result showing relacorilant added to chemotherapy produced a 35% reduction in risk of death in platinum‑resistant ovarian cancer, meeting a...
Macrophage‑targeted CAR T reshapes tumor microenvironment — preclinical survival gains
Researchers at the Icahn School of Medicine at Mount Sinai reported preclinical results in Cancer Cell showing IL‑12‑producing CAR T cells designed to target tumor‑associated macrophages (TAMs)...
Tumor plasticity and MYC immune‑silencing revealed — new targetable biology
Two mechanistic cancer studies outlined how tumors evade therapy and immune detection. A Cell paper showed high‑MYC tumors suppress innate immune signaling by binding nascent RNA and recruiting...
NIH stops fetal‑tissue research funding — Congress moves to shield the agency
The National Institutes of Health announced it would end support for research using fetal human tissue, a policy shift critics call political rather than scientific. The termination affects...
NVIDIA‑Lilly $1 billion AI lab: Discovery pushed to scale
NVIDIA and Eli Lilly announced a $1 billion collaboration to build an AI‑powered drug discovery laboratory in the San Francisco Bay Area. The pact combines NVIDIA’s computing and AI stack with...
Guardant wins FDA CDx nod — patent fight remanded to PTAB
Guardant Health received FDA approval for its Guardant360 CDx as a companion diagnostic to guide use of Pfizer’s Braftovi‑cetuximab chemotherapy regimen for BRAF V600E colorectal cancer, while a...
Corxel raises $287M to advance oral GLP‑1: Global phase plans funded
Corxel Pharmaceuticals closed a $287 million Series D to propel its oral small‑molecule GLP‑1 receptor agonist CX‑11 through ongoing U.S. phase II studies and planned global trials, and to prepare...
Sanofi to file amlitelimab — mixed Phase 3 muddies pathway
Sanofi said it will pursue global regulatory submissions for amlitelimab in atopic dermatitis despite mixed Phase 3 results. One pivotal study met primary and key secondary endpoints, while a...
BMS bets on Janux: $850M deal to develop tumor‑activated T‑cell engagers
Bristol Myers Squibb struck an exclusive collaboration and license with Janux Therapeutics to develop a tumor‑activated therapeutic derived from Janux’s TRACTr platform, with up to $850 million in...
Macrophage‑targeting CAR T resets tumor microenvironment — preclinical survival gains
Researchers at the Icahn School of Medicine at Mount Sinai reported preclinical data showing IL‑12–producing CAR T cells targeted to tumor‑associated macrophages (TAMs) reprogram the tumor...
Singapore scientists reveal 'bodyguard' for mutant EGFR: P2Y2‑integrin axis
A*STAR researchers identified a membrane‑proximal survival mechanism that stabilizes mutant EGFR in non‑small cell lung cancer: extracellular ATP activates the P2Y2 receptor, which recruits...
Corcept’s relacorilant shows survival gain — phase 3 ovarian win lifts outlook
Corcept Therapeutics reported that relacorilant, an oral selective glucocorticoid receptor antagonist, reduced risk of death by 35% in a Phase 3 study for platinum‑resistant ovarian cancer,...
Encodia shutters lab operations: ProteoCode protein‑sequencing startup folds
San Diego protein‑sequencing company Encodia ceased operations and began auctioning laboratory equipment after filing an assignment for the benefit of creditors in California. The collapse halts...
Venter‑led Diploid Genomics launches: AI genomics analytics spinout debuts
The J. Craig Venter Institute announced a new spinout, Diploid Genomics, launching with seed support from Healthier Capital to build an AI‑driven genomics analytics platform for research and...
NVIDIA, Lilly invest $1B in AI drug lab
NVIDIA and Eli Lilly announced a $1 billion collaboration to build an AI-powered drug discovery laboratory in the San Francisco Bay Area. The pact will combine NVIDIA’s computing platforms with...
FDA clears Guardant360 as companion test for Pfizer colorectal combo
The U.S. Food and Drug Administration approved Guardant Health’s Guardant360 CDx as a companion diagnostic to identify BRAF V600E‑mutant metastatic colorectal cancer patients for Pfizer’s...
Bristol Myers inks pact with Janux – up to $850M
Bristol Myers Squibb agreed an exclusive collaboration and licensing deal with Janux Therapeutics for a tumor‑activated T‑cell engager program, paying $50 million up front with potential...
Corcept’s relacorilant posts survival gain in ovarian cancer
Corcept Therapeutics reported Phase 3 data showing that relacorilant added to chemotherapy reduced risk of death by 35% in platinum‑resistant ovarian cancer, meeting a prespecified overall...
Corxel secures $287M to advance oral GLP‑1 program
Corxel Pharmaceuticals closed a $287 million Series D to advance CX‑11, an oral small‑molecule GLP‑1 receptor agonist licensed from Vincentage, through ongoing U.S. Phase II obesity trials and...