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AI-driven discovery of anti-glycation compounds from natural sources
Innovators from Toho University have developed an automated Carbonyl-Trapping Mechanism-Based Automatic Mining (CTM-AM) tool integrating high-performance liquid chromatography and mass...
Mechanistic insights into Parkinson's disease from parkin-deficient neuron studies
A multidisciplinary team has illuminated the molecular mechanisms driving Parkinson’s disease pathology by investigating seeding-competent α-synuclein aggregates within human induced pluripotent...
Breakthrough in cancer drug resistance tracking with genetic barcoding
Researchers have pioneered a novel method to track the dynamic evolution of cancer cell resistance to therapies by integrating genetic barcoding with quantitative phenotypic analysis. This...
Nanoparticle coassembly system improves drug delivery for chemotherapy
An innovative nanoparticle platform combining medical-grade poly(lactic-co-glycolic acid) (PLGA) with natural albumin protein has been developed, demonstrating exceptional improvements in...
Therapeutic potential of menin inhibition in aggressive acute leukemias
Recent progress in targeted cancer therapies highlights menin inhibitors as transformative agents for treating acute leukemias harboring KMT2A gene rearrangements and related mutations. Menin, a...
High-momentum 2D photoluminescence emission coupled with surface resonance
A new photonics study reveals a novel phenomenon wherein photoluminescence emissions exhibit high momentum two-dimensional propagation facilitated by coupling with surface lattice resonances...
Lanthanide–Carbon Triple Bond Inside Fullerene: A New Frontier in Chemistry
Researchers from a collaborative team in China and Singapore have achieved a landmark breakthrough by synthesizing and characterizing a cerium–carbon triple bond stabilized within an endohedral...
Novo Nordisk Amylin Drug Shows Strong Weight Loss but Dose Efficacy Questions Arise
Novo Nordisk's new amylin-targeting obesity drug, amycretin, demonstrated significant weight loss in a Phase 1/2 study, with the highest dose group losing an average of 24.3% body weight over 36...
Vertex Diabetes Cell Therapy Enables Most Patients to Discontinue Insulin
Vertex Pharmaceuticals reported that their investigational off-the-shelf stem cell therapy, zimislecel (previously VX-880), enabled 10 out of 12 type 1 diabetes patients to stop insulin therapy...
FDA Leadership Changes Signal Possible Shifts in Cell and Gene Therapy Oversight
Recent organizational changes within the U.S. FDA have led to the administrative leave and departure of top leadership in the Center for Biologics Evaluation and Research's Office of Therapeutic...
Artificial Intelligence Advances Propel Drug Discovery and Design
Recent innovations in artificial intelligence are dramatically accelerating biology and drug development. KAIST researchers have improved text-to-image generative models to generate more creative,...
Nanoparticle Drug Delivery Enhanced by Protein-Polymer Coassembly
Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have engineered a novel nanoparticle system integrating the biodegradable polymer PLGA with blood protein albumin to form...
Parkinson’s Disease Research Yields Insights on Protein Aggregates and Therapies
New studies illuminate molecular mechanisms central to Parkinson’s disease (PD). Investigations reveal that parkin-deficient human dopaminergic neurons derived from iPSCs generate α-synuclein...
Gilead’s HIV Prevention Injection Yeztugo Approved—A Biannual PrEP Milestone
Gilead Sciences attained FDA approval for Yeztugo (lenacapavir), the first twice-yearly injectable pre-exposure prophylaxis (PrEP) drug for HIV prevention. Clinical trials demonstrated up to 100%...
Breakthroughs in Neuroblastoma Therapy Using Human Amniotic Membrane Extracts
A pioneering study demonstrates that extracts from the human amniotic membrane (hAME) significantly potentiate the anti-cancer efficacy of doxorubicin in neuroblastoma cells by impeding...
Novel In Vivo CAR T Cell Generation via Targeted Lipid Nanoparticles
A transformative immunotherapy approach enables in vivo generation of chimeric antigen receptor (CAR) T cells directly within patients using antibody-conjugated lipid nanoparticles (tLNPs). These...
Cerium–Carbon Triple Bond Confined in Fullerene Cage
Researchers have achieved a landmark synthesis of a cerium–carbon triple bond encapsulated inside an endohedral fullerene, specifically a Ce≡CSc2 cluster within a C80 carbon cage. This work,...
FDA Review and Regulatory Innovations
The U.S. Food and Drug Administration (FDA) has initiated a pilot program led by Commissioner Martin Makary aimed at streamlining and accelerating the drug review process for medicines addressing...
Transformative Advances in Alzheimer’s Disease and Neurodegeneration
Recent discoveries have provided new insights into molecular mechanisms underlying Alzheimer's and Parkinson's diseases. Researchers have elucidated the pivotal role of α2,6-sialylation in...
Innovations in Cancer Therapies and Resistance Prediction
Significant progress is underway in cancer research focusing on acute leukemias, colorectal cancer, and drug resistance mechanisms. A novel therapeutic target combining histone acetyltransferases...