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FDA psychedelics push via priority vouchers
President Trump signed an executive order directing the FDA and other federal agencies to accelerate research and improve access to psychedelic drugs for serious mental illnesses, using...
WHO prequalification expands antimalarial access for infants
The World Health Organization has prequalified Coartem Baby, Novartis’ antimalarial combination for infants, in a milestone that expands WHO-recognized treatment options for younger children. The...
Checkpoint blockade combination supports organ preservation in MSI-H GC
Durvalumab (Imfinzi) combined with tremelimumab (Imjudo) produced high survival and deep response signals in cohort 2 of the INFINITY phase 2 trial in resectable microsatellite instability-high...
Cell therapy platform aims to engineer glycocalyx for B-lymphoma adoptive therapy
A new paper in Engineering outlines advances in live-cell glycocalyx engineering to improve adoptive cell therapies for B-cell lymphoma. The work frames glycocalyx optimization as a way to address...
CAR-neutrophils are engineered for glioma in vivo
Researchers reported progress toward direct genetic programming of neutrophils for glioma by developing in vivo CAR-neutrophils. The approach targets a key historical barrier: neutrophils have...
Regulatory science and trial design: synthetic control arms reshape evidence generation
An Innovation Spotlight argues that synthetic control arms—generated from external datasets instead of traditional placebo groups—are changing how investigators plan clinical trials. The piece...
AI microscopy captures sharper real-time movies in live cells
Engineers at the University of California San Diego developed an AI-enhanced microscopy workflow that produces images with twice the sharpness of conventional microscopes while capturing at video...
Diagnostics: smart finger-cuff algorithm finds moderate-to-severe aortic stenosis with high accuracy
A study presented at SCAI 2026 Scientific Sessions and the CAIC-ACCI Summit in Montreal reported high-accuracy performance of a smart finger-cuff algorithm for detecting moderate-to-severe aortic...
Epigenetic vulnerability: KMT2C/D loss creates targetable cancer weaknesses
Researchers reported that loss of the epigenetic regulators KMT2C/D creates targetable vulnerabilities in cancer. The work connects tumor dependency to COMPASS-related biology, focusing on how...
Innovative TB readout: deep learning estimates Mtb antibiotic resistance and treatment response
A deep learning framework using convolutional neural networks (CNNs) was reported to quantify Mycobacterium tuberculosis antibiotic resistance and predict patient responses to treatment. The...
Psychedelic drug acceleration via White House executive action
President Donald Trump signed Executive Order 14401, directing the FDA and other federal agencies to accelerate research and expand access for psychedelic drugs intended to treat serious mental...
WHO prequalification advances infant antimalarial access
The World Health Organization has prequalified Coartem Baby, Novartis’ antimalarial combination medicine for infants. Novartis developed the product in partnership with Medicines for Malaria...
EMA CHMP turns positive on Sanofi’s MS therapy while diverging on an FDA setback
EMA’s CHMP recommended approval of Sanofi’s BTK inhibitor Cenrifki (tolebrutinib) for secondary progressive multiple sclerosis at its April meeting, following a different outcome on the U.S. side....
Lanifibranor readout outlook drives leadership changes at Inventiva
Inventiva added senior leadership to its C-suite as it prepares for a Phase III readout for lanifibranor in metabolic dysfunction-associated steatohepatitis (MASH) expected in 4Q26. The company...
AI-enhanced microscopy enables sharper real-time imaging inside live cells
Researchers at the University of California San Diego reported an AI-enhanced microscopy workflow that delivers crisper, real-time video of events occurring inside living cells. The method is...
New fluorescent tool maps centrioles and cilia in living cells
EPFL researchers introduced CenSpark, a fluorescent probe designed to visualize centrioles and cilia inside living cells across species. The tool aims to make it easier to study structures central...
Engineering glycocalyx on adoptive cell therapies for B lymphoma
A new study in Engineering describes approaches to glycocalyx engineering for adoptive cell therapies targeting B lymphoma. The report frames glycocalyx modification as a way to address...
Neural circuit screening links TRPV4 to aminoglycoside hearing toxicity
Researchers reported evidence that TRPV4 drives aminoglycoside ototoxicity without reducing antimicrobial efficacy. The study highlights a mechanism in which the TRPV4 channel influences both...
More validation for MS-like mouse model driven by B cells and TH17
A study clarified how B cells and T helper 17 (TH17) cells contribute to experimental autoimmune encephalomyelitis, the commonly used mouse model for multiple sclerosis. The work addresses a...
Synthetic control arms spotlight alternative trial design for harder-to-study diseases
A Qureight innovation spotlight lays out how synthetic control arms use external datasets to compare treatment effects, aiming to reduce dependence on traditional placebo-controlled designs. The...