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Novartis agrees up to $3B for Pikavation – adds mutant‑selective PI3Kα
Novartis struck a deal to acquire Pikavation for up to $3 billion, paying roughly two‑thirds up front to add SNV4818, a mutant‑selective PI3Kα inhibitor, to its oncology portfolio. Pikavation is a...
CytomX’s ADC posts 32% ORR in mCRC... Stock whipsaws after data
CytomX reported positive dose‑expansion Phase I data for varsetatug masetecan (varseta‑M) in metastatic colorectal cancer, showing a 32% overall response rate and median progression‑free survival...
AI fuels N‑of‑1 medicine... Bespoke therapies move from idea to pilots
Researchers and industry leaders at the 2026 Precision Medicine World Conference argued that AI, advanced protein‑folding models, and high‑frequency personal data are enabling ‘N‑of‑1’...
World’s brightest X‑rays map intact organs: New open‑access organ atlas
Researchers used the world’s brightest X‑ray sources to image intact human organs at unprecedented resolution and launched an open‑access portal to explore the datasets. The project provides...
Cellares: Automation, closed systems and networks to scale cell therapy
Cellares argued that automation, closed manufacturing systems, and global production networks are the path to making cell therapy a broadly accessible medicine. Fabian Gerlinghaus outlined...
How DICER cuts microRNAs: Single‑nucleotide precision revealed
A team at HKUST unveiled the molecular mechanism by which human DICER processes precursor microRNAs with single‑nucleotide precision. The study mapped structural features and catalytic steps that...
Acinetobacter capsules reshape antibiotic resistance and immune evasion
Researchers reported that structural variations in Acinetobacter capsules influence both antibiotic resistance and host immune recognition. The study dissected how capsule composition alters drug...
New live‑attenuated VEE vaccines advance as outbreak countermeasure
Researchers developed novel live‑attenuated vaccine candidates for Venezuelan equine encephalitis virus (VEEV) to address a persistent arboviral threat lacking a broadly licensed human vaccine....
Utah pilots AI refill bot: Researchers flag security and safety gaps
Utah began piloting an autonomous prescription‑refill chatbot developed by Doctronic to streamline routine renewals and improve adherence. A Mindgard AI report, however, identified vulnerabilities...
GlassWorm hides malware in invisible text... Open‑source supply chain at risk
Security researchers uncovered a campaign dubbed GlassWorm that embeds malicious payloads in open‑source contributions using invisible Unicode characters. Attackers submitted seemingly benign code...
Novartis pays up to $3B for Pikavation – adds PI3Kα mutant‑selective asset
Novartis agreed to acquire Pikavation Therapeutics for up to $3 billion to add SNV4818, a mutant‑selective PI3Kα inhibitor, to its oncology pipeline. The deal includes a multi‑hundred‑million...
Study: sepsis tied to nearly 20% of US pediatric hospital deaths
A national analysis published in JAMA quantified pediatric sepsis burden and found sepsis implicated in nearly one in five pediatric hospital deaths across the United States. The study provided...
Measles surge and ACIP upheaval... US vaccine policy in flux
Public‑health researchers reported sustained measles circulation in the U.S., with over 1,300 cases so far this year and ongoing outbreaks in multiple states, reversing two decades of elimination...
AI systems enter clinical care—trial shows benefit, security researchers raise alarms
A cluster‑randomized clinical trial published in The BMJ showed that an AI‑driven clinical decision support system improved quality of care and long‑term outcomes for acute ischemic stroke...
Scientists identify genes that let some people suppress HIV without ART
Researchers at Gladstone Institutes reported discovery of two genes that help certain individuals maintain long‑term HIV remission without daily antiretroviral therapy. The work maps molecular...
Startup pays donors for menstrual blood to build stem‑cell biobank
San Francisco startup Muse Bio began paying women to donate menstrual fluid as it builds a biobank of menstrual‑derived stem cells, aiming first at cosmetics and later at regenerative‑medicine...
Environment and bacteria reshape antimicrobial risk—unexpected exposures surface
Two studies highlighted rising antimicrobial risks from environmental contamination and bacterial defenses. Researchers documented accumulation of antibiotics in a major Brazilian river—with...
Single‑cell tools map cells to outcomes and reveal cardiac repair signals
Two teams released advances that couple single‑cell resolution with predictive and mechanistic insights. A new computational framework, scSurv, integrates bulk and single‑cell RNA sequencing to...
Molecular discoveries alter therapy landscape—ATGL, DICER reveal new levers
Two molecular studies report findings with translational implications. Researchers showed Adipose Triglyceride Lipase (ATGL) can sensitize hepatocellular carcinoma cells to chemotherapy through...
Neonatal care studies deliver actionable signals—neurobehavior links and surfactant null result
A Journal of Perinatology study linked NNNS‑II neurological profiles to pharmacologic treatment trajectories among infants exposed prenatally to opioids, providing a potential tool to stratify...