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AI redesigns antibodies into live-cell reporters — Colorado State
Researchers at Colorado State University described an AI-driven workflow to modify antibodies so they act as intracellular fluorescent probes, enabling visualization of specific protein activities...
Enterococcus redox metabolism blocks wound healing — target found
An NTU Singapore and University of Geneva team published in Science Advances that Enterococcus faecalis deploys extracellular electron transport (EET) to generate reactive oxygen species,...
Targeting innate immunity: cGAS–STING mapped — MERTK inhibitor disrupts efferocytosis
Two complementary reports highlight innate-immune targets shaping cancer immunity and inflammation. A review of the cGAS–STING pathway synthesizes opportunities and challenges for cancer therapy,...
Sarepta’s Elevidys shortfall — CEO defends sales as stock slips
Sarepta Therapeutics reported preliminary Q4 2025 results showing Elevidys (delandistrogene moxeparvovec-rokl) sales of $110.4 million, a quarter-on-quarter decline that missed analyst forecasts...
FDA backs Hemostemix basket approach — regulator signals support
Hemostemix received FDA support for its basket protocol approach, a regulatory milestone the company says will streamline the development of its platform across multiple indications. The...
FDA expedited approvals under fire: who will sign off?
Reporting has surfaced internal legal and procedural questions around the FDA’s new expedited drug program, including who within the agency is willing to sign final approvals and whether standard...
NIH FY2026 at stake: advocates urge House to preserve $48.7B
Advocates are calling on House appropriators to adopt the Senate-approved FY2026 NIH funding level of $48.7 billion and to retain Senate language protecting indirect cost policies and multi‑year...
Real-time metabolic monitoring: deeper control for cell and gene therapy
Industry voices including Tia Harmon at PHCNA are spotlighting real‑time metabolic monitoring technologies that deliver earlier intervention points in complex cell and gene therapy (CGT)...
AI agents move into oncology labs — from classification to decision-making
Researchers and companies are accelerating deployment of AI agents that go beyond classification to assist experimental design, hypothesis generation, and therapeutic decision pathways in...
Dormant metastases go soft — MSK shows shape‑shift shields cells from immunity
Memorial Sloan Kettering researchers report in Nature Cancer that disseminated cancer cells can enter a TGFβ‑driven program that ultimately transitions cells into a round, low‑tension morphology,...
E. faecalis redox metabolism impairs healing — study points to new therapies
An international team led by NTU Singapore and the University of Geneva reports in Science Advances that Enterococcus faecalis uses extracellular electron transport (EET) to generate reactive...
Unedited CD7 CAR‑Ts beat T‑cell leukemia in preclinical tests — fratricide exploited
A study in the Journal of Translational Medicine describes a fratricide‑driven strategy using unedited CD7 CAR‑T cells to treat T‑cell acute lymphoblastic leukemia. Rather than genetically...
Whole-transcriptome diagnostics validated: 1,233 FFPE tumor cohort reported
Researchers led by Ball, Beck, and Wlochowitz published a large‑scale diagnostic study in the British Journal of Cancer showing that whole‑transcriptome sequencing performs robustly across 1,233...
Sarepta sales miss opens fresh gene‑therapy safety questions – stock tumbles
Sarepta Therapeutics reported preliminary Q4 2025 product sales that fell short of analyst expectations, driven by weaker-than-forecast revenue for its AAV gene therapy Elevidys and a decline in...
TGFβ drives shape switch in dormant lung metastases… immune evasion mechanism revealed
Researchers at Memorial Sloan Kettering Cancer Center reported that TGFβ signaling induces an atypical epithelial‑to‑mesenchymal transition that ultimately converts disseminated lung...
Enterococcus faecalis redox metabolism implicated in chronic wound failure – new therapeutic target
An international team led by NTU Singapore and the University of Geneva identified extracellular electron transport (EET) in Enterococcus faecalis as a mechanism that generates reactive oxygen...
Fratricide‑driven, unedited CD7 CAR‑T shows efficacy in T‑cell leukemia models
A team publishing in the Journal of Translational Medicine described fratricide‑driven, unedited CD7 CAR‑T cells as a promising therapy for T‑cell leukemia. The approach leverages the tendency of...
Two‑step genome editing creates full‑length humanized mouse models – new tool for in vivo human gene studies
Researchers developed a two‑step genome‑editing workflow to replace mouse loci with full‑length human sequences, enabling creation of humanized mouse models that preserve human regulatory...
Real‑time metabolic monitoring enters cell and gene therapy manufacturing workflows
PHCNA coverage highlights the deployment of real‑time cell metabolic monitoring technologies in cell and gene therapy (CGT) manufacturing to enable earlier interventions and tighter process...
FDA signals support for Hemostemix basket protocol approach
Regulatory commentary and a community submission note that Hemostemix received favorable engagement from the FDA for its basket protocol strategy, according to a public post. The interaction...