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FDA Cancer Regulator’s Intervention Affects Approval Outcomes
Reports reveal that Richard Pazdur, head of the FDA’s Oncology Center of Excellence, directly influenced the rejection of Replimmune’s melanoma drug RP1 by overruling the Center for Biologics...
Early Insights Into ALS Mutation and Therapeutic Targeting
Scientists at Case Western Reserve University report that the familial ALS-linked VAPB P56S mutation activates the integrated stress response (ISR) via mitochondrial dysfunction in motor neurons....
New Bacterial Therapy Bypasses Immune System in Cancer
Researchers at JAIST partnered with Daiichi Sankyo and the University of Tsukuba have unveiled an innovative cancer treatment using bacteria that operates independent of the immune system. This...
GSK and Hengrui Lead Biopharma Deals in Asia
GlaxoSmithKline struck deals with Jiangsu Hengrui Pharma to develop up to 12 medicines, including a PDE3/4 inhibitor HRS-9821 for COPD with a $500 million upfront fee and potential $12 billion...
Twist Bioscience Raises Fiscal Guidance on Strong Q3 Performance
Twist Bioscience reported an 18% revenue increase in fiscal Q3 2025, driven by 27% growth in next-generation sequencing and 7% in synthetic biology. The company shipped approximately 237,000...
Biopharma Industry Signals Through FDA Leadership Changes
FDA leadership upheavals, including the departure of Vinay Prasad from Center for Biologics Evaluation and Research (CBER), have stirred notable market reactions. Analysts anticipate benefits for...
Environmental Microplastics and Their Emerging Health Implications
Groundbreaking environmental and health studies reveal pervasive micro- and nanoplastics across terrestrial and aquatic ecosystems, human feces, and bloodstreams, raising alarming possibilities...
Cancer Immunotherapy and Tumor Microenvironment Advances
Recent breakthroughs highlight sophisticated immune-targeting strategies to combat tumors. Novel approaches include CAR macrophages engineered via mRNA extracellular vesicles to reduce lung...
Neuroscience Reveals Epigenetic and Circuitry Mechanisms
Cutting-edge neurobiological research uncovers novel mechanisms underlying brain function and disease. Key findings include histone lactylation regulating pain response via DOCK4 modulation,...
Precision Megabase Genome Editing Breaks New Ground in Eukaryotic Cells
Researchers led by Professor Gao Caixia of the Chinese Academy of Sciences have pioneered Programmable Chromosome Engineering (PCE), achieving kilobase to megabase-scale precise genome...
GSK and Asian Biotechs Form Massive Alliances in Drug Development
GlaxoSmithKline has entered an extensive collaboration with Jiangsu Hengrui Pharma to develop up to 12 novel medicines, including a PDE3/4 inhibitor targeting COPD, with upfront payments totaling...
San Diego Biotech Faces Market Downturn and Regulatory Challenges
San Diego's biotech sector experiences a sharp slowdown, with increased lab vacancies and difficulty in securing new roles, as detailed by interviews with displaced workers such as former Illumina...
Advances in AI and Deep Learning Propel Cancer and Medical Imaging
New AI-driven models are revolutionizing cancer diagnostics and medical imaging. Notably, a deep learning algorithm precisely predicts 1p/19q co-deletion in gliomas, enhancing non-invasive...
Microplastic Pollution: Novel Methods and Emerging Health Risks
Recent research deepens understanding of microplastics' environmental dissemination and health implications. Studies report plastic particle infiltration into human feces, gut cells, and...
Innovations in Cancer Immunotherapy and Tumor Targeting Strategies
Breakthroughs in cancer treatment emerge with novel therapeutic modalities. CAR macrophages delivered via mRNA-loaded extracellular vesicles demonstrate efficacy against lung metastasis....
Public and Regulatory Developments in Obesity Treatment Coverage
The Centers for Medicare and Medicaid Services (CMS) reconsider coverage of GLP-1 receptor agonists for obesity management after previously rescinding a Biden-era proposal. The agency contemplates...
Breakthroughs in Neuroscience Reveal Novel Insights into Memory and Brain Diseases
Recent neuroscientific advances illuminate key mechanisms underlying memory and neurodegeneration. Studies depict how human insula-hippocampus interactions coordinate episodic memory encoding,...
Major Deals and Strategic Moves in Biopharma Corporate Landscape
In a notable industry shift, Xoma Royalty Corporation acquired two struggling biotechs, HilleVax and Lava Therapeutics, in deals involving cash and milestone payments aimed at revitalizing...
Novel Diagnostic and Therapeutic Advances in Cancer Management
Cutting-edge studies are advancing cancer diagnosis and treatment. Researchers introduce a nomogram combining body composition and tumor burden to accurately predict lymph node metastasis in early...
China’s Programmable Chromosome Editing Surpasses Megabase Scale
Researchers led by Professor Gao Caixia from the Chinese Academy of Sciences have developed novel Programmable Chromosome Engineering (PCE) systems enabling megabase-scale precision genome editing...