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Innovations in Cell Therapy Manufacturing and Immune Activation Tools
Collaborations are emerging to scale and optimize cell therapy manufacturing. Sartorius Stedim Biotech partnered with Nanotein Technologies to commercialize NanoSpark soluble activators that...
Cancer Immunotherapy and Vaccine Development Faces Mixed Outcomes
Immunotherapy and cancer vaccines are showing varied clinical results. Pfizer’s antibody-drug conjugate Padcev, combined with Merck’s Keytruda, demonstrated meaningful survival benefits in bladder...
Bayer and Kumquat's $1.3 Billion KRAS Cancer Collaboration
Bayer has entered an exclusive global licensing and collaboration agreement with Kumquat Biosciences to develop and commercialize Kumquat’s investigational KRAS G12D inhibitor. This move targets a...
Insmed’s Brinsupri Approved As First Treatment for Bronchiectasis
Insmed's brensocatib (Brinsupri) has received FDA approval as the first treatment for non-cystic fibrosis bronchiectasis, a chronic lung condition affecting approximately 500,000 Americans....
Novel AI and Machine Learning Advances in Gene Editing
Researchers have integrated artificial intelligence (AI) and deep learning techniques to enhance precision and predictability in gene editing. A study from the University of Zurich introduced...
AI-Powered Tools Transform Cancer Diagnosis and Therapeutics
Artificial intelligence continues to shape oncology by providing improved diagnostics and drug development pathways. The Radiological Society of North America’s AI Challenge showcased models that...
Challenges and Developments in Biopharma Financing and Real Estate
The life sciences sector faces headwinds amid rising real estate vacancies and cooling venture capital (VC) funding, particularly evident in the Greater Boston area where lab space vacancies have...
Breakthroughs in Neurodegenerative Disease Research and Therapies
Recent studies have unveiled novel mechanisms and therapeutic candidates targeting neurodegenerative diseases. Mitochondrial dysfunction's causal role in Alzheimer’s and dementia was countered...
Cancer Vaccine and Immunotherapy Trials Yield Mixed Outcomes
Multiple oncology immunotherapy programs report critical trial updates. IO Biotech's phase 3 trial for the off-the-shelf cancer vaccine Cylembio narrowly missed its primary endpoint when combined...
AI and Digital Health Innovations in Diagnostics and Patient Care
Advancements in artificial intelligence and digital technologies are transforming diagnostics and patient management. Mount Sinai researchers developed AI models predicting hospital admissions...
Regulatory and Industry Shifts Impacting Biotech and Pharma
The biotech and pharmaceutical sectors face significant regulatory and operational developments. The FDA reinstated Vinay Prasad as CBER director amid controversy and political pressures....
Insmed’s Brinsupri Hits Market – New Bronchiectasis Drug Gains FDA Nod
Insmed’s Brinsupri (brensocatib) became the first FDA-approved treatment specifically for non-cystic fibrosis bronchiectasis (NCFB), a chronic lung disorder afflicting approximately 500,000 U.S....
Bayer Seals $1.3B Deal for KRAS G12D Cancer Drug – Trial Ready After IND
Bayer entered an exclusive global licensing and collaboration agreement with Kumquat Biosciences to develop and commercialize a KRAS G12D inhibitor, potentially worth over $1.3 billion. Kumquat...
Novartis Scores Twin Phase 3 Wins – Ianalumab Advances in Autoimmune Diseases
Novartis’ monoclonal antibody ianalumab achieved statistically significant results in two separate phase 3 studies targeting Sjögren’s syndrome and primary immune thrombocytopenia (ITP). This...
AI-Driven Precision Genome Editing – Deep Learning Designs Microhomology Templates
Researchers from the University of Zurich developed an artificial intelligence tool, Pythia, that predicts cellular DNA repair outcomes to improve precision genome editing. Combining deep learning...
Cancer Vaccine Nears Approval Despite Phase 3 Setback – IO Biotech Eyes FDA Talks
IO Biotech’s off-the-shelf cancer vaccine, Cylembio, narrowly missed the primary endpoint of progression-free survival in a phase 3 melanoma trial but showed encouraging data in patient subgroups...
Novel Protein-Based Antidote Emerges for Carbon Monoxide Poisoning
University of Maryland School of Medicine researchers engineered a breakthrough protein therapy that acts as a fast, selective antidote for carbon monoxide (CO) poisoning. Published in PNAS, the...
Rapid Oxygenated Macroencapsulation Sustains Insulin Cells for Diabetes Therapy
Cornell University researchers developed an oxygenated macroencapsulation system named BEAM that enables high-density transplant and survival of insulin-producing cells without immunosuppression...
AI and Data Analytics Propel Biopharma Monitoring and Coding Accuracy
Pharmaceutical companies are increasingly embracing data analytics and artificial intelligence (AI) to enhance clinical trial monitoring, compliance, and medical coding accuracy. Experts from Sage...
Decoding Cold Sores: Host Enzyme Targeted to Prevent HSV-1 Latency
A team led by Esther González-Almela at Guangdong Academy of Medical Sciences revealed that herpes simplex virus type 1 (HSV-1) hijacks host enzymes RNA polymerase II and topoisomerase 1 (TOP1)...