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Novel Fusion Architecture Employs Semi-Supervised Learning for Parkinson’s Detection via Speech
Researchers have pioneered a fusion architecture combining multiple machine learning models employing semi-supervised speech embeddings to detect Parkinson’s disease through subtle vocal...
Innovative Nanoparticle System Enhances Drug Delivery Stability and Loading
Scientists from Xi’an Jiaotong-Liverpool University and Nanjing University have engineered a protein-polymer coassembly supraparticle combining PLGA polymer and albumin protein, achieving...
FDA Initiates Pilot Program for Accelerated Drug Review Supporting National Priorities
FDA Commissioner Marty Makary announced a pilot Commissioner’s National Priority Voucher (CNPV) program aimed at expediting the review of medicines that address U.S. national interests, including...
Prothena Cuts Workforce by 63% After Phase 3 Amyloidosis Drug Failure
Biotech company Prothena announced a substantial workforce reduction, laying off 63% of its employees following the failure of its phase 3 trial for the monoclonal antibody birtamimab targeting...
Lanthanide–Carbon Triple Bond Discovery in Fullerene
Researchers have achieved a landmark breakthrough in organometallic chemistry by isolating a lanthanide–carbon triple bond encapsulated within a fullerene cage. This study reports the synthesis...
Menin Inhibition Emerges for Acute Leukemia Treatment
In a critical advancement against aggressive acute leukemias, menin inhibitors are gaining traction as novel targeted therapies. AML and ALL, characterized by uncontrolled proliferation due to...
In Vivo CAR T Cell Generation via Targeted Lipid Nanoparticles
A transformative innovation in immunotherapy has been unveiled whereby chimeric antigen receptor (CAR) T cells can be generated directly within patients rather than ex vivo. By utilizing lipid...
Gilead’s Lenacapavir FDA Approval for Twice-Yearly HIV Prevention
Gilead Sciences received FDA approval for its long-acting injectable HIV pre-exposure prophylaxis drug, lenacapavir (Yeztugo), marking a major step forward in preventing HIV infection....
Zealand Pharma’s Dual GLP-1/GLP-2 Agonist Shows Weight Loss Potential
Zealand Pharma has presented updated phase 1b clinical trial data for dapiglutide, a dual glucagon-like peptide-1 and -2 receptor agonist, which induced a mean body weight reduction of 11.6% after...
Breakthrough in Artificial Cells with Model Nuclei via Microfluidics
Researchers at Chuo University, led by Professor Hiroaki Suzuki, have developed a cutting-edge method for mass-producing artificial cells containing model nuclei using microfluidic technology. The...
Breakthrough Stem Cell Method Produces Canine Mesenchymal Stem Cells
Osaka Metropolitan University researchers have pioneered a novel technique to generate high-quality mesenchymal stem cells (MSCs) from canine induced pluripotent stem cells (iPSCs). By...
Novel Non-Contact Terahertz Spectroscopy Measures Buried PN Junctions
A pioneering non-destructive technique has been developed to precisely determine the depth of buried PN junctions in silicon wafers through terahertz (THz) emission spectroscopy. By stimulating...
Breakthrough Imaging Identifies Early Parkinson’s via Speech Fusion Architecture
Advancements integrating artificial intelligence with neurological diagnostics have led to the development of a fusion architecture leveraging semi-supervised speech embeddings for early detection...
FDA Leadership Shakeup in Cell and Gene Therapy Division Sparks Industry Concern
The Food and Drug Administration has placed the director and deputy of its cell and gene therapy office on administrative leave, escorting both out of the agency. This sudden leadership departure,...
Lanthanide-carbon triple bond stabilized inside fullerene cage
Researchers at the frontier of coordination and organometallic chemistry have synthesized a unique lanthanide–carbon triple bond encapsulated within an endohedral fullerene cage, specifically a...
Therapeutic Potential of Menin Inhibition in Acute Leukemias
Acute leukemias, notably acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), are aggressive hematologic malignancies characterized by dysregulated hematopoietic proliferation,...
In vivo creation of CAR T cells via targeted lipid nanoparticles
Researchers have innovated a novel immunotherapeutic strategy enabling the in vivo generation of chimeric antigen receptor (CAR) T cells, bypassing traditional ex vivo cell manufacturing....
Advancements in nanoparticle drug delivery with protein-polymer coassembly
Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have developed a novel nanoparticle system by coassembling PLGA, a biodegradable medical polymer, with albumin, a naturally...
Gilead gains FDA approval for twice-yearly HIV PrEP injection Yeztugo
The FDA has approved Gilead Sciences’ lenacapavir (Yeztugo) as the first twice-yearly injection for pre-exposure prophylaxis (PrEP) against HIV. Clinical trials demonstrated nearly 100% efficacy...
Virtual Reality Enhances Stroke Rehabilitation Outcomes
A comprehensive Cochrane review encompassing 190 trials and over 7,000 stroke patients highlights virtual reality (VR) as a beneficial adjunct therapy for improving arm motor function during...