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CirCode wins FDA clearance: US trial to test circular RNA therapy
CirCode Biomed secured FDA authorization to start a U.S. clinical trial of its circular RNA therapeutic platform, the company told Endpoints News. The clearance allows the China‑based startup to...
Signal Bioscience pitches high‑plex PCR: seed round and partner hunt
Signal Bioscience unveiled a chemistry that decouples amplification from signal generation to drive higher multiplexing in dPCR and qPCR while lowering costs, the startup said in an interview....
CMS backs NeoGenomics liquid biopsy: PanTracer LBx gets coverage
CMS granted coverage for NeoGenomics' PanTracer LBx, a blood‑based comprehensive genomic profiling assay intended to inform therapy selection and clinical trial enrollment for advanced solid...
Oral GLP‑1 posts 16% weight loss... Structure aims phase‑3 push
Structure Therapeutics published Phase 2 results showing its oral GLP‑1 agonist aleniglipron achieved roughly 16% mean weight loss versus placebo at 44 weeks, positioning the company to escalate...
Unnatural Products nets $45M — macrocycles move toward clinic after Novartis pact
Unnatural Products closed a $45 million Series B to accelerate its macrocyclic peptide discovery platform and advance lead programs toward the clinic, the company announced. The round was led by...
CytomX posts ADC data in late‑line CRC — Varseta‑M shows activity
CytomX disclosed clinical data from late‑line metastatic colorectal cancer patients treated with its antibody‑drug conjugate varsetatug masetecan (Varseta‑M), reporting responses across multiple...
HER2 ADC posts ~53% response in urothelial cancer — RC48 data
Disitamab vedotin (DV), a HER2‑targeted antibody‑drug conjugate, produced confirmed overall response rates of roughly 53–55% in a phase 2 cohort of previously treated metastatic urothelial...
Alliance launches Phase III for grade‑3 IDH‑mutant astrocytoma
The Alliance for Clinical Trials in Oncology opened a randomized Phase III study testing an intensified regimen for patients with grade‑3 IDH‑mutant astrocytoma, the group announced. Supported by...
Team revives neuronal activity in vitrified mouse brains — PNAS report
A research team in Germany demonstrated restoration of some neuronal activity and cellular functions in vitrified and thawed mouse brains, publishing methods and results in Proceedings of the...
Genetic code expanded: five noncanonical amino acids encoded at once
Researchers reported a method to simultaneously incorporate five distinct noncanonical amino acids (ncAAs) into a single protein in mammalian cells, a milestone for synthetic biology and protein...
Waste plastic to Parkinson’s drug: bacteria-made L‑DOPA
Researchers report a method that engineers bacteria to convert post‑consumer plastic bottles into L‑DOPA, the frontline medication for Parkinson’s disease. The study describes a biosynthetic...
Genetic code expansion: five noncanonical amino acids in one protein
A synthetic‑biology team demonstrated simultaneous incorporation of five distinct noncanonical amino acids (ncAAs) into a single protein in mammalian cells, expanding the functional repertoire...
HER2 ADC posts >50% response in advanced urothelial cancer
Phase‑2 RC48G001 data presented at the ASCO Genitourinary Cancers Symposium show the HER2‑targeting antibody‑drug conjugate disitamab vedotin (DV) produced confirmed overall response rates around...
Lantheus gets tentative FDA nod for Lutathera copy – patent clash looms
The FDA issued a tentative approval for Lantheus’ abbreviated new drug application PNT2003 — a planned generic alternative to Novartis’ radioligand Lutathera — even though Novartis has active...
Vitamin B2 metabolism shields tumors from ferroptosis: CRISPR screen
A CRISPR–Cas9 screen identified riboflavin (vitamin B2) metabolism as a key modulator of ferroptosis resistance in cancer cells, supporting stability of ferroptosis suppressor protein 1 (FSP1) and...
Long‑acting cabotegravir–rilpivirine alters monocyte immunity in people with HIV
A study characterizing immune changes in people living with HIV (PLWH) who switched from daily oral therapy to long‑acting injectable cabotegravir plus rilpivirine reports notable shifts in...
Researchers restore activity in vitrified mouse brains — partial function returns
A German team reports that vitrification plus a tailored thawing protocol preserved and restored aspects of neuronal function in mouse brains, including neuronal firing, cellular metabolism and...
TYK2 drives neuroinflammation in Alzheimer’s with TDP‑43 pathology
A Nature Communications study identifies TYK2 as a central mediator of neuroinflammation in Alzheimer’s disease brains exhibiting TDP‑43 pathology. The authors show that TYK2 activation amplifies...
ICU transmission pathways of multidrug‑resistant Acinetobacter documented
Genomic and epidemiologic analyses reveal how multidrug‑resistant Acinetobacter baumannii spreads within intensive care units, mapping transmission networks and identifying environmental and...
Global federated AI builds prognostic models for anal cancer
An international consortium developed prognostic models for anal cancer using federated learning to train algorithms across multiple centers without sharing raw patient data. The work, detailed in...