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Novel Antibody-Bottlebrush Conjugates Enhance Cancer Drug Delivery
MIT researchers developed antibody-bottlebrush prodrug conjugates (ABCs) that dramatically increase drug loading on antibodies from a traditional max of eight to hundreds of molecules. This...
Advances in Prime Editing Reduce Genome Editing Errors
MIT scientists engineered prime editing variants with mutations in Cas9 nickase to destabilize nicked DNA ends, promoting precise DNA repair and dramatically lowering insertion/deletion mutations...
New TB Gene Therapy Diagnostic Enables One-Pot CRISPR Test
A team led by Tulane University and Shenzhen Third People's Hospital developed an improved one-pot CRISPR assay for tuberculosis utilizing recombinase polymerase amplification alongside...
Roche’s $3.5B 89bio Buyout Exands MASH Drug Pipeline
Roche is acquiring 89bio for $2.4 billion upfront with up to $1.1 billion in milestone payments for pegozafermin, a late-stage FGF21 analog targeting metabolic dysfunction-associated...
CRISPR Activation Reverses SCN2A Haploinsufficiency in Mice
Researchers from UCSF have demonstrated a novel CRISPR activation (CRISPRa) approach that boosts expression of the functional SCN2A gene copy in a mouse model mimicking human neurodevelopmental...
AI Models Transform Disease Risk Prediction and Drug Discovery
A new generative AI model trained on UK Biobank data predicts risks for over 1,000 diseases up to 20 years in advance, leveraging lifestyle and health records to enable early preventive...
CRISPR-Based TB Tests Advance Affordable Screening Solutions
Scientists from Tulane University and Shenzhen Third People's Hospital developed an improved CRISPR-Cas12a based tuberculosis test, ActCRISPR-TB, which offers rapid, sensitive detection without...
Immunotherapy and Cancer Mechanisms Investigations Reveal Novel Targets
Multiple studies have unveiled critical insights into cancer biology and therapeutics. Indiana University scientists identified dual protein targets to weaken pancreatic cancer cell defenses....
Controversy Mounts Over CDC Vaccine Panel and Immunization Recommendations
Recent upheaval at the U.S. Centers for Disease Control and Prevention involves political interference in vaccine policy decisions. Former CDC director Susan Monarez testified that Health...
Biogen’s New Kendall Square Headquarters Signals Growth Amid Industry Challenges
Biogen marked the groundbreaking for its 16-story Kendall Square headquarters in Cambridge, Massachusetts, anticipating completion by 2028 as it celebrates its 50th anniversary. CEO Christopher...
Antibody-Bottlebrush Conjugates Offer New Cancer Treatment Platform
MIT researchers created antibody-bottlebrush prodrug conjugates (ABCs) that dramatically increase drug-to-antibody ratios, carrying hundreds of drug molecules per antibody versus the conventional...
Advances in Brain-Computer Interfaces and Neural Sensing Technology
Researchers developed novel flexible, soft, and multifunctional bioelectronic fibers capable of dense sensing and stimulation within ultra-small, stretchable architectures, overcoming limitations...
Roche’s Strategic $3.5B 89bio Acquisition Accelerates MASH Drug Development
Roche has agreed to acquire 89bio in a deal potentially worth up to $3.5 billion, acquiring pegozafermin, a late-stage Phase 3 candidate targeting metabolic dysfunction-associated steatohepatitis...
CRISPR-Based TB Test Promises Accessible Tuberculosis Screening
Researchers from Tulane University and Shenzhen Third People's Hospital have developed ActCRISPR-TB, an improved CRISPR-Cas12a assay enabling rapid, affordable tuberculosis diagnosis using...
CDC Vaccine Panel Changes Spark Public Health Concerns
Tensions mounted at the U.S. Centers for Disease Control and Prevention (CDC) as Secretary of Health and Human Services Robert F. Kennedy Jr. restructured the Advisory Committee on Immunization...
AI Model Forecasts Risks for Over 1,000 Diseases Decades Ahead
A novel generative AI model, Delphi-2M, trained on extensive UK Biobank data from over 400,000 individuals, can simultaneously predict the likelihood and timing of developing more than 1,000...
Breakthrough CRISPR Activation Improves Neurodevelopment in SCN2A Haploinsufficiency
Scientists at UCSF demonstrated that CRISPR activation (CRISPRa) can boost expression of the functional SCN2A gene copy in a mouse model of SCN2A haploinsufficiency, a leading cause of...
Immunotherapy Advances in Glioblastoma and Cancer Treatment Mechanisms
Recent research reveals promising strategies against glioblastoma and other cancers: a study uncovers how glioblastoma cells detach and increase lethality via cellular plasticity; another...
Biotech Startups Secure Major Funding to Drive Innovation and Expansion
Biotech firms continue to attract substantial investment, fueling innovation and growth. Colossal Biosciences raised an additional $120 million in Series C financing to advance de-extinction and...
Innovations in Gene Therapy and Antibody Conjugates Targeting Cancer and Rare Diseases
Recent biotech developments demonstrate advanced modalities in gene and antibody therapies. Shape Therapeutics partnered with VectorY Therapeutics in a $1.2 billion deal leveraging a...