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Novartis pays $2B for mutant‑selective PI3Kα pill – broadens breast cancer arsenal
Novartis agreed to buy Synnovation Therapeutics’ PI3Kα program, paying $2 billion upfront to acquire SNV4818, a mutant‑selective oral inhibitor in early clinical testing. The deal transfers rights...
AI drugmaker Earendil hauls in $787M – scales biologics pipeline
Earendil Labs closed a $787 million financing round to accelerate an AI‑driven biologics pipeline spanning autoimmune disease and oncology. Founder and CEO Jian Peng said the capital lets the...
FDA insists on sham surgery control for uniQure’s Huntington’s gene therapy
The FDA told uniQure it will require a prospective, randomized, double‑blind sham surgery‑controlled study to support a marketing application for AMT‑130, an AAV‑delivered gene‑lowering therapy...
Tumor whole‑genome sequencing shows broad clinical utility – Nature Medicine
A real‑world study published in Nature Medicine evaluated paired tumor‑normal whole‑genome sequencing (WGS) in 888 patients and found clinical utility across solid tumors. WGS succeeded in 89% of...
Engineered esophagus restores function in pig model – step toward pediatric therapy
Researchers at Great Ormond Street Hospital and UCL reported in Nature Biotechnology that an autologous, engineered esophageal segment successfully replaced a circumferential portion of esophagus...
CytomX draws $250M after varsetatug ADC data – funds expansion
CytomX completed a $250 million follow‑on offering after releasing Phase I data for its EpCAM‑targeting ADC, varsetatug masetecan (Varseta‑M), which showed a 32% objective response rate in...
Excalipoint secures $68.7M to push masked T‑cell engagers into clinic
Shanghai‑based Excalipoint raised $68.7 million in a seed round to advance three T‑cell engager platforms and a trispecific candidate now in the clinic. The company plans to develop...
AI clinical decision support improves stroke outcomes in randomized trial
A cluster‑randomized clinical trial published in The BMJ showed that an AI‑driven clinical decision support system (CDSS) improved processes of care and long‑term outcomes for patients with acute...
Utah pilots autonomous Rx refill bot — researchers flag security flaws
Utah launched a pilot to let an AI system from Doctronic autonomously process routine prescription refills to cut delays and boost adherence. A security report from Mindgard AI subsequently...
AI‑powered OCT analytics map wound healing dynamics – Duke/Nokia
Duke University engineers and Nokia Bell Labs developed an AI pipeline that analyzes optical coherence tomography (OCT) data to quantify wound healing in real time. The tool extracts structural...
Novartis pays $2 billion — buys Synnovation’s PI3Kα candidate
Novartis announced an up-front $2 billion acquisition of Pikavation Therapeutics, a Synnovation Therapeutics subsidiary, securing experimental PI3Kα inhibitor SNV4818. The deal aims to bolster...
AI biotech Earendil bags $787M — readies clinic push
Earendil Labs closed a $787 million financing to accelerate a broad pipeline of AI-designed biologics, the company said. The round included venture investors Dimension and Luminous Ventures plus...
FDA insists on sham surgery for uniQure’s Huntington’s gene therapy
The U.S. Food and Drug Administration told uniQure it requires a prospective, randomized, double‑blind, sham surgery‑controlled study to support marketing approval for AMT‑130, the company’s...
Roche halts emugrobart program — patients notified
Roche said it will stop development of emugrobart, an experimental treatment for spinal muscular atrophy (SMA), after a key study failed to show consistent improvements in muscle growth and motor...
Tumor WGS shows broad real‑world utility — 888‑patient study
A real‑world series of 888 patients published in Nature Medicine demonstrates that paired tumor‑normal whole‑genome sequencing (WGS) succeeds in 89% of cases with a median turnaround of six...
Lab‑grown esophagus restores swallowing in growing pig model
Researchers at Great Ormond Street Hospital and UCL reported in Nature Biotechnology that an autologous engineered esophageal segment successfully integrated and restored swallowing in growing...
AI decision support improves stroke care — cluster RCT in BMJ
A cluster‑randomized clinical trial published in The BMJ found that an AI‑driven clinical decision support system (CDSS) improved care quality and long‑term outcomes for patients with acute...
Automation push aims to make cell therapy a scalable medicine
Cellares executives outlined how automation, closed manufacturing systems, and global manufacturing networks could convert individualized cell therapies into broadly available medicines. The...
CytomX, Alto raise cash to support clinical programs
Public markets activity included CytomX’s $250 million follow‑on offering, executed after positive Phase I data for its EpCAM ADC varsetatug masetecan showing a 32% objective response rate in...
FDA clears four NMEs — approvals hit 26 in first two months
The U.S. Food and Drug Administration cleared four new molecular entities (NMEs) in the opening months of 2026, bringing the total to 26 approvals across January and February. The newly approved...