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FDA Greenlights Pembrolizumab for Resectable Head and Neck Cancer
The FDA has approved pembrolizumab for patients with resectable locally advanced head and neck squamous cell carcinoma expressing PD-L1, marking a significant therapeutic advancement. This...
UC Scientists Reveal Protein Structures Driving Inflammatory Diseases
University of Cincinnati researchers used cryogenic electron microscopy to visualize for the first time the ADAM17 enzyme bound to its regulator iRhom2, key to inflammatory signaling linked to...
Proteomics Integration Advances Multiomics Research Platforms
Ultima Genomics and collaborators enhance multiomics capabilities by integrating gene sequencing and proteomics technologies to better characterize biological systems. Partnerships with firms like...
New Cooling Technology Aims to Cut Data Center Energy Use
University of California San Diego engineers developed a novel fiber membrane technology that passively cools data centers through evaporation, potentially halving energy consumption versus...
Seed Round Fuels Elkedonia’s Neuroplastogen for Depression Treatment
French startup Elkedonia secured €11 million in seed funding to advance its ELK-1 inhibitor targeting refractory depression. ELK-1 influences neuroplasticity and reward circuits implicated in mood...
Cancer Immunotherapy Advances: Dual-Target CAR-T Shows Promise in Lymphoma
Johnson & Johnson presents clinical data from a Phase 1b trial of a dual CD19/CD20-targeted CAR-T therapy for relapsed or refractory large B-cell lymphoma. High objective and complete response...
Shift in Biotechnology Governance Marking 50 Years of Asilomar Principles
Following the 50th anniversary of the 1975 Asilomar Conference on Recombinant DNA, Rice University archived 27 entreaties emphasizing governance of modern biotechnology. These documents address...
Novo Nordisk Advances Amycretin Obesity Drug into Phase 3 Trials
Novo Nordisk plans Phase 3 clinical trials for amycretin, a dual GLP-1 and amylin receptor agonist, investigating both injectable and oral formulations. The move comes after positive phase 1b/2a...
Parkinson’s Disease Penetrance Linked to GBA1 Variant Severity and Genetics
A study in npj Parkinson’s Disease identifies variant severity and polygenic background as determinants of Parkinson’s disease penetrance among GBA1 mutation carriers. The findings enhance...
Fusobacterium nucleatum: Unveiling Cancer’s Microbial Ally in Colorectal Disease
A comprehensive review by researchers at the Institute of Process Engineering illuminates the extensive role of Fusobacterium nucleatum in colorectal cancer development. The bacterium's ability to...
BioNTech Buys CureVac to Accelerate Cancer Therapy Development
BioNTech's $1.25 billion all-stock acquisition of CureVac strengthens its mRNA manufacturing and cancer immunotherapy pipeline. By integrating CureVac’s manufacturing capabilities and resolving...
TIGIT Setbacks Expose Pitfalls of Immunotherapy Hype
Failures of major anti-TIGIT antibody candidates, following promising early results, reveal challenges in immuno-oncology development. Key phase 3 trials halted due to lack of efficacy underscore...
Fusobacterium nucleatum's Role in Colorectal Cancer Uncovered: Pathways and Therapeutic Avenues
Recent research led by Wei Wei and Diwei Zheng at the Institute of Process Engineering highlights Fusobacterium nucleatum (Fn) as a major driver in colorectal cancer (CRC) progression. This oral...
UC San Diego Unveils Evaporative Cooling Membrane to Slash Data Center Energy Use
Engineers at the University of California, San Diego have introduced an innovative fiber membrane technology enabling passive evaporative cooling for data centers and high-powered electronics....
New PET Imaging Method Enables In Vivo Tracking of CAR-T Cells in Immunotherapy
Researchers at Technical University of Munich have developed a novel PET imaging technique that enables clinicians to visualize engineered CAR-T cells within the body. The method involves...
Rapid Vascular Organoid Generation via Dual Transcription Factor Activation
Boston Children’s Hospital and Harvard Medical School scientists have developed a fast, well-defined method to generate functional 3D vascular organoids from human induced pluripotent stem cells....
TIGIT Antibody Failures Spotlight Challenges in Immuno-Oncology Investment
The once-hyped immuno-oncology target TIGIT has encountered significant setbacks, with leading drugs like BeOne Medicines’ ociperlimab and GSK’s belrestotug discontinued after disappointing...
Thermo Fisher Considers Diagnostics Divestment Amid Market Pressures
Thermo Fisher Scientific’s shares dropped over 1% following reports of exploring a sale of part of its diagnostics unit, including its microbiology business, with a potential valuation of around...
Immunai Partners with Parker Institute to Enhance AI Immune Models Using Single-Cell Data
Immunai has entered a partnership with the Parker Institute for Cancer Immunotherapy to generate an extensive single-cell gene expression dataset from a cancer patient cohort receiving immune...
City of Hope Reveals Tumor ecDNA Maps, Enabling Personalized Brain Cancer Insights
City of Hope scientists have co-led research that characterizes extrachromosomal DNA (ecDNA) in brain tumors, linking these structures to oncogene activity and hypoxic tumor microenvironments. The...