Researchers at the University of Cologne have optimized the CUT&Tag assay by lowering salt concentrations, enabling detection of transient transcription factor-DNA interactions previously masked. This improvement, named DynaTag, allowed visualization of binding dynamics of oncogenic factors like c-Myc, including changes post-chemotherapy in small-cell lung cancer models. The enhanced method offers a powerful tool for epigenetic and gene regulation studies at single-cell resolution.