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Rapid Generation of Vascular Organoids Enhances Regenerative Medicine Potential
Researchers at Boston Children’s Hospital and collaborators have developed a rapid, defined method to generate vascular organoids from human induced pluripotent stem cells via simultaneous...
Anticancer Therapy Advances through Dual-Targeting CAR-T and Menin Inhibitors
Early clinical data reveal Johnson & Johnson's dual-targeting CD19/CD20 CAR-T therapy achieving up to 100% response rates in some lymphoma patients, while menin inhibitor combination therapy in...
Quantum Clocks Advance Global Time Measurement and Fundamental Physics
An international consortium conducted the largest coordinated optical clock comparison to date, spanning six countries and simultaneous operations of clocks and interlinking networks. These...
Novel Catalyst Breaks Down Persistent PFAS Chemicals at Ambient Conditions
Researchers at Goethe University Frankfurt have developed a boron-based catalyst embedded in a carbon framework that efficiently cleaves stubborn carbon–fluorine bonds in PFAS compounds at room...
Exercise Mobilizes Brain Cells Protecting Against Alzheimer’s Disease Pathology
A single-nucleus RNA sequencing study identified that physical activity modifies gene expression in Alzheimer’s disease mouse models, notably enhancing responses in microglia and...
FDA Approves UroGen’s Bladder Cancer Hydrogel Despite Adcom Vote
The FDA approved UroGen's hydrogel drug Zusduri for low-grade, intermediate-risk, non-muscle invasive bladder cancer despite a narrowly negative advisory committee vote. Clinical trial data...
BioNTech Moves to Settle Dispute, Buys CureVac for $1.25 Billion
BioNTech is acquiring CureVac in an all-stock deal valued at $1.25 billion, effectively ending prolonged patent litigation over mRNA vaccine technology. The transaction strengthens BioNTech's...
ADC Therapeutics Cuts UK R&D, Lays Off 30% Amid Pipeline Setbacks
ADC Therapeutics announced the closure of its U.K. research site, layoffs of 30% of staff, and discontinuation of several preclinical oncology programs after dropping its sole clinical candidate...
FDA Clears Urogen’s Zusduri Despite Advisory Panel Doubts
The U.S. Food and Drug Administration approved UroGen’s bladder cancer hydrogel, Zusduri, intended for low-grade, intermediate-risk, non-muscle invasive bladder cancer. Approval comes despite a...
BioNTech Acquires CureVac to Settle mRNA Patent Dispute
BioNTech has agreed to acquire CureVac in a $1.25 billion all-stock transaction, ending years of patent litigation over mRNA vaccine technology. The deal values CureVac’s shares at a 55% premium...
Novel Acute Myeloid Leukemia Combination Shows Promise in Early Trial
A phase 1 trial combining revumenib, an oral menin inhibitor, with standard azacitidine and venetoclax demonstrated high complete remission rates in patients with acute myeloid leukemia harboring...
Physical Exercise Engages Brain Cells to Protect Against Alzheimer’s
Using single-nucleus RNA sequencing, researchers identified that physical activity influences specific hippocampal cell types—microglia and neurovascular-associated astrocytes—in mouse models of...
Rapid Vascular Organoid Generation for Regenerative Medicine
Researchers developed a method to quickly generate vascular organoids from human induced pluripotent stem cells by simultaneous activation of transcription factors ETV2 and NKX3.1. This technique...
FDA Expands Moderna RSV Vaccine Use to Broader Adult Population
The U.S. FDA authorized Moderna’s mRESVIA respiratory syncytial virus vaccine for use in additional adult populations aged 18 to 59 at risk for RSV infection, broadening availability beyond older...
Advancements in AI Improve Neural Network Training Efficiency
Scientists at the Technical University of Munich demonstrated that pretraining artificial neural networks with biological data from mouse retinal waves significantly enhances prediction accuracy...
Industry and Policy Update: Biopharma Investment, Regulatory Shift and Strategic Appointments
Biopharma continues to experience robust public and private financing in 2025, with new IPOs and funding rounds reported. Key regulatory updates include FDA approvals such as Nuvation Bio’s...
Groundbreaking Optical Clock Network Advances Timekeeping Precision
Researchers across six countries conducted the most extensive simultaneous comparison of optical atomic clocks, creating a network spanning thousands of kilometers. This distributed system...
AI-Driven Broad-Spectrum Coronavirus Drug Emerges from Cambridge
A multidisciplinary team at Harvard's Wyss Institute leveraged AI-enabled molecular modeling and physics-based simulations to identify and optimize bemcentinib derivatives with antiviral activity...
Pembrolizumab Approved by FDA for Perioperative Head and Neck Cancer
The U.S. Food and Drug Administration granted approval to pembrolizumab as a perioperative treatment for resectable locally advanced head and neck squamous cell carcinoma expressing PD-L1. This...
FDA Approves UroGen’s Zusduri for Low-Grade Bladder Cancer
Despite a narrowly negative advisory committee vote, the FDA approved UroGen’s hydrogel formulation for recurrent low-grade, intermediate-risk non-muscle invasive bladder cancer based on high...