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CRISPR Screens Identify Genetic Enhancements for CAR T in Multiple Myeloma
Scientists at Mass General Brigham and the Broad Institute have leveraged CRISPR screens to pinpoint gene modifications that boost chimeric antigen receptor T (CAR T) cell function and persistence...
Breakthrough RSV Prevention Advances Immunization for Vulnerable Infants
The fight against respiratory syncytial virus (RSV), a leading cause of infant hospitalization worldwide, has seen remarkable advances with novel vaccines and monoclonal antibodies. Newly approved...
Acadia Pharmaceuticals Abandons Prader-Willi Syndrome Drug After Phase III Failure
Acadia Pharmaceuticals has ceased development of its intranasal drug ACP-101 for treating hyperphagia in Prader-Willi syndrome after a 12-week Phase III trial failed to meet its primary endpoint...
Sanofi Ventures Boosts Biotech Investment with $625 Million Funding
Sanofi has increased its corporate venture capital arm, Sanofi Ventures, by $625 million, bolstering its capacity to invest in early- and late-stage biotechnology and digital health companies....
AI and Robotics Propel Drug Discovery and Clinical Research
Artificial intelligence and robotics are increasingly integral in biotech, powering faster drug discovery and more efficient clinical trials. Lila Sciences secured $235 million Series A funding to...
FDA Grants Clearance to Next-Generation Immuno-Oncology and Diagnostic Tools
The FDA approved Merck’s Keytruda Qlex, a subcutaneous PD-1 immune checkpoint inhibitor injection that can be administered in about a minute, enhancing treatment convenience for solid tumors....
Insights into Chromosomal Rearrangements Illuminate Genome Evolution and Stability
Researchers at the Stowers Institute have precisely mapped the DNA breakpoints responsible for the formation and propagation of human Robertsonian chromosomes, a common structural variant...
Pest Resistance Threatens Effectiveness of Latest Corn Biotech Defenses
New studies published in the Proceedings of the National Academy of Sciences reveal that corn rootworms, a significant agricultural pest, are rapidly evolving resistance to even the newest...
UniQure’s Gene Therapy Slows Huntington’s Disease Progression by 75%
UniQure reported pivotal Phase I/II trial results for AMT-130, its gene therapy targeting Huntington’s disease. The high-dose treatment achieved a statistically significant 75% reduction in...
Scholar Rock’s Spinal Muscular Atrophy Drug Faces FDA Rejection over Manufacturing Issues
Scholar Rock’s SMA treatment apitegromab received a complete response letter from the FDA due to unresolved manufacturing quality concerns at a contract facility owned by Novo Nordisk. The issues...
AI and CRISPR Advance Cancer Immunotherapy: Genetic Screens Enhance CAR T Cell Efficacy
Researchers at Mass General Brigham and the Broad Institute leveraged CRISPR screens to identify gene knockouts that improve CAR T cell function and persistence against multiple myeloma. Using...
FDA Clears Subcutaneous Keytruda: First One-Minute Immune Checkpoint Injection
The FDA approved Merck’s Keytruda Qlex, a subcutaneously administered combination of pembrolizumab and berahyaluronidase alfa, becoming the first immune checkpoint inhibitor delivered under a...
Sanofi Boosts Venture Capital with $625M Cash Infusion for Biotech Investments
Sanofi has bolstered its corporate venture capital arm, Sanofi Ventures, with an additional $625 million, bringing total committed capital to approximately $1.4 billion. The financing aims to...
Breakthrough RSV Preventatives Cut Infant Illness and Death, Expanding Protection
2023 saw the approval of the first single-dose RSV vaccine and monoclonal antibody treatments, offering unprecedented protection against severe respiratory syncytial virus infection in infants and...
Triclabendazole Blocks PKM2 Enzyme, Disrupting Lung Cancer Metabolism
A novel application of triclabendazole, traditionally an antiparasitic drug, has demonstrated promising activity against lung cancer by targeting the enzyme Pyruvate Kinase M2 (PKM2). This...
New ‘Live-seq’ Workflow Enables Non-Damaging Live-Cell RNA Sequencing for Dynamic Studies
Cytosurge and Lexogen have launched the first commercial integrated Live-seq workflow, enabling repeated RNA sequencing of the same living cells with minimal invasiveness. This breakthrough...
AI-Driven Virtual Specialty Care Platform AmplifyMD Raises $20M Series B
AmplifyMD secured $20 million in Series B funding to expand its AI-powered virtual specialty care platform and physician network aimed at filling specialty provider gaps and enhancing healthcare...
UniQure Gene Therapy Slows Huntington’s Disease Progression by 75%
UniQure announced positive topline results from its pivotal Phase I/II trial of AMT-130 gene therapy targeting Huntington’s disease, demonstrating a statistically significant 75% reduction in...
CRISPR Screens Reveal Genetic Enhancements for CAR T Cell Cancer Therapies
Researchers from Mass General Brigham and the Broad Institute utilized comprehensive CRISPR genetic screens to identify key gene knockouts that significantly improve CAR T cell proliferation,...
Bespoke Bacteriophage Therapies Tackle Antimicrobial-Resistant Superbugs
Monash University and The Alfred Hospital researchers have developed a tailored bacteriophage therapy cocktail, Entelli-02, specifically targeting antimicrobial-resistant pathogens. This...