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STING–TGF‑β–PD‑L1 triple targeting magnifies CXCL16–CXCR6 tumor response
Researchers reported that simultaneously modulating STING, TGF‑β, and PD‑L1 pathways dramatically enhances antitumor immunity through activation of the CXCL16–CXCR6 axis. The triple-targeting...
LRRK2 R1627P intensifies gut inflammation and α‑synuclein in models
A translational study showed that the Parkinson’s-linked LRRK2 R1627P mutation amplifies gut inflammation and promotes α‑synuclein aggregation in rat models. Investigators reported increases in...
CCMB finds fungal metabolic switches that enable invasion and alter antifungal response
Scientists at the Centre for Cellular and Molecular Biology (CCMB) reported that metabolic programs in fungi underpin invasive behavior and determine responsiveness to antifungal therapy. The team...
Las Vegas raid: Israeli-linked biolab leaves residents 'deathly ill' — FBI seizes samples
Las Vegas police and federal agents arrested an Israeli national, Ori Salomon (aka Ori Solomon), after a residential property used as an alleged biological laboratory reportedly left several...
Hims halts compounded GLP‑1 sales after federal and industry legal pressure
Telehealth company Hims & Hers announced it would stop offering a compounded version of Novo Nordisk’s Wegovy following legal threats from federal regulators and pressure from Novo Nordisk. The...
OpenEvidence hits $12B valuation — doctors driving adoption, pharma ads follow
OpenEvidence reached a $12 billion valuation as investor demand climbed behind its clinician‑first AI medical search tool, which the company says is used regularly by more than 430,000 clinicians....
Hims halts GLP‑1 sales — FDA legal threat forces U‑turn
Hims & Hers abruptly stopped offering a compounded version of Novo Nordisk’s Wegovy after escalating legal pressure from U.S. federal regulators and threats of enforcement action. The company...
Roivant’s brepocitinib clears proof‑of‑concept — pivotal test next
A Priovant Therapeutics proof‑of‑concept study showed brepocitinib, a dual JAK1/TYK2 inhibitor licensed from Pfizer, met its goals in cutaneous sarcoidosis — a rare inflammatory skin disorder with...
Las Vegas raid seizes makeshift biolab — Israeli national arrested, samples sent to FBI
Las Vegas police arrested an Israeli national after discovering a residential property configured as an apparent biological laboratory with freezers, a biosafety hood, centrifuge and more than...
OpenEvidence valuation hits $12B: 430,000 clinicians using free AI search
OpenEvidence’s reported $12 billion valuation reflects rapid clinical adoption of its doctor‑first AI medical search tool, which the company says is used regularly by more than 430,000 clinicians...
Phage plus antibiotic halts resistant peritonitis — synergy shown in Nature Communications
Researchers publishing in Nature Communications reported that a bacteriophage‑antibiotic combination successfully cleared refractory peritoneal dialysis‑related peritonitis caused by Klebsiella...
Inflammasome protein ASC rewires pancreatic cancer metabolism — Nature Communications
A 2026 Nature Communications paper identified the inflammasome‑associated protein ASC as a molecular link between innate immune signaling and mitochondrial metabolism in pancreatic cancer cells....
3D gut‑brain‑vascular model exposes gut‑driven neuropathology
A team publishing in Nature Communications unveiled a 3D gut‑brain‑vascular platform that models bidirectional communication among gut, neural and vascular tissues. The system recapitulates...
Parkinson’s‑linked LRRK2R1627P mutation ramps gut inflammation — rat study ties to α‑synuclein
Researchers report that the LRRK2 R1627P mutation intensifies gut inflammation and accelerates α‑synuclein aggregation in rat models, linking a genetic Parkinson’s risk factor to early gut...
Nitazene deaths likely underreported by up to 33% — King’s College finds
A Clinical Toxicology study from King’s College London found that fatalities involving nitazene synthetic opioids may be undercounted by as much as one‑third, owing to limitations in toxicology...
Charles River and Thermo Fisher cut staff — site closures trigger layoffs
BioSpace’s layoff tracker reported workforce reductions at major contract research and laboratory services providers including Charles River and Thermo Fisher Scientific alongside site closures....
Hims halts compounded GLP‑1 program: Regulators close in
Hims & Hers stopped offering a compounded version of Novo Nordisk’s Wegovy after escalating federal pressure and legal threats. The company said it “decided to stop offering access” to the...
Roivant posts proof‑of‑concept win – Brepocitinib eyes pivotal testing
Priovant Therapeutics, a Roivant Sciences subsidiary, reported that brepocitinib—a dual JAK1/TYK2 inhibitor licensed from Pfizer—met endpoints in a proof‑of‑concept study in cutaneous sarcoidosis....
Sanofi unveils failed tolebrutinib data – PPMS program collapses
Sanofi disclosed detailed results from a failed Phase 3 trial of the BTK inhibitor tolebrutinib in primary progressive multiple sclerosis (PPMS). The company’s presentation at ACTRIMS highlighted...
Phage plus antibiotic clears resistant peritonitis in preclinical model
Researchers reported in Nature Communications that combining bacteriophage therapy with antibiotics eradicated refractory Klebsiella pneumoniae peritonitis in a preclinical peritoneal dialysis...