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Blood biomarkers track Alzheimer’s across cognitive stages — Nature Communications
A Nature Communications study validated blood biomarkers that correspond to Alzheimer’s disease progression across cognitive stages in community cohorts. The research identified plasma signatures...
Automated MRI system flags clinically significant prostate cancer
A Nature Communications paper described an automated MRI system that reliably identifies clinically significant prostate cancer, integrating image processing and machine learning to standardize...
Thermal one‑pot CRISPR: rapid on‑site viral surveillance
Researchers published a thermally programmed, one‑pot CRISPR assay in Nature Communications that integrates thermal control with CRISPR molecular recognition to enable rapid, sensitive viral...
Iambic: AI and automation shrink chemistry‑to‑clinic to two years
San Diego startup Iambic reported that physics‑informed algorithms combined with automated chemistry have shortened its chemistry‑to‑clinic timeline to roughly two years, according to a BioCentury...
Sydnexis setback highlights FDA opacity — CRL raises concerns
BioCentury reported that Sydnexis received a complete response letter (CRL), a regulatory setback that staff and commentators say underscores growing concerns about FDA transparency and shifting...
Biotech follow‑ons raise nearly $950M — markets stay open
On Nov. 21, four biotech companies—Nuvalent, Olema, Invivyd and Inhibikase—priced follow‑on equity offerings that collectively approached $950 million, according to BioCentury’s public equity...
Plasma NGS reshapes NSCLC care in Asia — study shows
A new BMC Cancer study reports that plasma‑based next‑generation sequencing (NGS) improves diagnostic yield and therapeutic selection in advanced non‑small cell lung cancer (NSCLC) within Asian...
CD4 memory T‑cell subset tied to type 1 diabetes — Science Immunology
A team at the University of Pennsylvania and the HPAP Consortium reported in Science Immunology a distinct CD4 memory helper T‑cell subset associated with type 1 diabetes (T1D). Researchers led by...
Automated MRI: AI system spots clinically significant prostate cancer
Researchers publishing in Nature Communications unveiled an automated MRI system designed to detect clinically significant prostate cancer with high reliability. The team led by Wu, Liu and Yang...
cfDNA fragment–chromatin correlation enables pan‑cancer detection
An international team introduced a pan‑cancer detection method that pairs cell‑free DNA (cfDNA) fragment coverage with chromatin accessibility patterns to identify cancer across tumor types and...
ASAH1 axis drives venetoclax resistance in AML
A 2025 BMC Cancer study identified ASAH1 and altered sphingolipid metabolism as drivers of venetoclax resistance in acute myeloid leukemia (AML), particularly in monocytic phenotypes. The research...
CombiCoR‑Vax phase II tests sequential immunotherapy and chemo in MSS mCRC
Researchers launched CombiCoR‑Vax, a phase II trial testing a sequential immunotherapy‑then‑chemotherapy regimen in patients with refractory microsatellite‑stable (MSS) metastatic colorectal...
Eli Lilly hits $1 trillion – obesity drugs power rally
Eli Lilly reached a historic market valuation of $1 trillion after sustained gains tied to its obesity drug franchise. Market reports and company data show that demand for GLP-1–class medicines...
Resalis ASO challenges GLP‑1s: precision obesity approach
Resalis Therapeutics presented data and preclinical rationale for an antisense oligonucleotide (ASO) targeting miR‑22 that it says produces precision weight loss and metabolic benefits,...
Ginkgo launches Virtual Cell Initiative: builds 12 billion datapoint resource
Ginkgo Bioworks’ Ginkgo Datapoints unit announced the Virtual Cell Pharmacology Initiative (VCPI), an open‑source effort to standardize virtual cell modeling for drug discovery and generate...
Iambic compresses chemistry‑to‑clinic to two years – AI and automation deliver
Iambic, a San Diego–based company, reported that physics‑informed algorithms and automation have shortened its chemistry‑to‑clinic cycle to about two years, delivering small molecules into...
Novartis to build U.S. manufacturing hub in North Carolina: end‑to‑end capacity planned
Novartis announced plans to establish a flagship manufacturing hub in North Carolina as part of a $23 billion U.S. infrastructure investment, adding biologics, sterile packaging, and solid‑dose...
DARPA vet Fisher tapped to lead UK research agency ARIA
The U.K. research funding agency ARIA named a former DARPA official, Fisher, as its new chief, according to BioCentury reporting. The appointment signals ARIA’s continued strategy of importing...
Ocean Diagnostics pushes rapid sepsis ID toward 2028 launch after perfect pilot
France‑based Ocean Diagnostics completed a pilot clinical evaluation showing its rapid sequencing–based blood test matched gold‑standard blood cultures at 100% concordance and detected additional...
Taiho and Cullinan file rolling NDA for zipalertinib – EGFR exon‑20 program advances
Taiho Pharmaceutical and Cullinan Therapeutics initiated a rolling NDA submission to the U.S. FDA for zipalertinib, seeking accelerated approval for patients with locally advanced or metastatic...