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Skyhawk and Merck KGaA Ink $2 Billion Neurological RNA Pact
Skyhawk Therapeutics and Merck KGaA announced a collaboration aiming to develop RNA splicing modulators targeting neurological diseases, with potential payments up to $2 billion. Skyhawk will...
Anocca Scores $46 Million to Pursue Pancreatic Cancer Cell Therapy
Swedish biotech Anocca secured roughly $46 million (SEK 440 million) to support clinical trials of VIDAR-1, its nonviral genome-edited TCR T-cell therapy targeting mutant KRAS in pancreatic...
AI-Driven Nanoparticles Accelerate RNA Therapy Development
A team at MIT developed COMET, an AI-powered platform utilizing transformer neural networks to design lipid nanoparticles that improve RNA delivery efficacy across various cell types. Published in...
Stealth BioTherapeutics Shares FDA Rejection to Rally Support
In an unusual move, Stealth BioTherapeutics publicly disclosed an FDA rejection letter concerning its Barth syndrome treatment. The biotech is campaigning to garner regulatory reconsideration,...
Breakthroughs in Breast Cancer and Glioma Molecular Research
New studies provide insights into cancer mechanisms and potential therapies. A large multi-center retrospective study found that ovarian function suppression improves outcomes in premenopausal...
Insmed’s First Drug for Non-CF Bronchiectasis Gains FDA Nod
Insmed received FDA approval for Brinsupri (brensocatib), the first therapy for non-cystic fibrosis bronchiectasis, addressing neutrophilic inflammation to reduce exacerbations. The approval...
Pfizer's Sickle Cell Drug Fails Phase 3 Endpoint
Pfizer’s inclacumab, a P-selectin inhibitor acquired from Global Blood Therapeutics, failed to meet primary efficacy endpoint in a Phase 3 study targeting vaso-occlusive crises in sickle cell...
US Government Cuts mRNA Vaccine Research Funding: Consequences
Recent reductions in U.S. government funding for mRNA vaccine research raise concerns about impacts on healthcare innovation and biotech R&D. The funding cuts may slow the advancement of mRNA...
Cancer Immunotherapy Advances – TOPK and c-Abl as New Targets
Recent studies highlight promising molecular targets in cancer immunotherapy. Research published in BMC Cancer reveals T-LAK cell-originated protein kinase (TOPK) drives immune suppression in...
Biotech Funding and Strategic Challenges – Oncology Patent Cliffs and VC Moves
The biotech sector faces significant financial shifts as major oncology drugs approach patent expiry. A comprehensive analysis details how blockbuster immuno-oncology therapies from the mid-2010s...
Neuroscience Breakthroughs – FOXP Genes and PTSD Brain Pathology
Groundbreaking research clarifies key mechanisms shaping brain function and mental health disorders. A new study uncovers the role of FOXP genes in generating Purkinje cell diversity and...
Alzheimer’s Disease Research – Microglia Dysfunction and Semaglutide Trials
Emerging studies address critical Alzheimer’s disease (AD) mechanisms and therapies. Purdue University researchers demonstrated amyloid beta plaques induce lipid droplet accumulation in microglia,...
Cutting-Edge Oncology Treatments – Cell Therapies and Immunotherapies
Innovative cancer treatments advance as Anocca raises $46 million to initiate early clinical trials of T cell receptor therapy targeting KRAS mutant pancreatic cancer. Additionally, immune...
Emerging Biomaterials and Battery Tech – MoS2/NC and High-Conductivity MXenes
Material science innovations deliver breakthroughs in energy and nanotechnology. Researchers introduced a novel MoS₂/nitrogen-doped carbon composite optimizing lithium-ion battery anodes for...
Digital and AI Innovations in Biotech Research
AI and digital tools streamline biomedical discovery and diagnostics. A machine learning model, AlphaCD, was developed to precisely characterize over 21,000 cytidine deaminases, accelerating...
Infant and Neonatal Care Innovations
Recent clinical research targets improved outcomes in vulnerable neonates. Intratracheal budesonide combined with surfactant shows promise for preterm infant lung protection, addressing...
Stem Cell and Fertility Research – Inducing Human Meiosis In Vitro
A novel stem cell differentiation method successfully induces meiosis bypassing the primordial germ cell stage, providing a new platform for studying human gametogenesis. Developed by Harvard's...
Environmental and Microbial Innovations – Bioplastics and Methane Research
Biotechnological advances impact sustainability and climate science. The bioplastics market is growing with polyhydroxyalkanoates (PHAs) emerging as biodegradable, tunable polymers from microbial...
Oncology Patent Cliff: Big Pharma Confronts Revenue Risks
The biotech industry faces a looming patent cliff in oncology as several blockbuster cancer drugs, including immunotherapies approved in the mid-2010s, approach loss of exclusivity within the next...
FDA Approves First Treatment for Non-CF Bronchiectasis: Insmed's Brinsupri
The FDA granted approval to Insmed's Brinsupri, a first-of-its-kind therapy targeting neutrophilic inflammation in non-cystic fibrosis bronchiectasis (NCFB), impacting approximately 500,000...