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Cold Spring Harbor Lab’s BATMAN AI Outperforms in TCR-Peptide Binding Predictions
Researchers at Cold Spring Harbor Laboratory developed BATMAN, an AI model trained on the expansive BATCAVE database of over 22,000 TCR-peptide interactions, achieving superior accuracy in...
TCG Labs Soleil Raises Additional $400M, Expands Biotech Startup Portfolio to China
TCG Labs Soleil, a venture firm specializing in creating single-drug biotechnology startups, secured an additional $400 million, doubling its initial fund to $800 million. The firm also launched...
Roche Faces Revenue Pressure from China Pricing Reforms Yet Sees Global Growth
Roche reported a 3% decline in diagnostic division revenues for H1 2025, weighed down by healthcare pricing reforms and volume-based procurement programs in China, leading to a 26% drop in local...
AstraZeneca’s Gefurulimab Meets Phase 3 Endpoints in Myasthenia Gravis Trial
AstraZeneca announced positive Phase 3 trial results for gefurulimab, a once-weekly, self-administered C5 complement inhibitor for adults with generalized myasthenia gravis who have...
AI Advances Enable Rapid Design of Protein Binders for Precision Immunotherapy
Scientists led by Nobel Laureate David Baker have harnessed AI-driven protein design to create highly specific, low-immunogenicity binders targeting diverse peptide-MHC complexes essential for...
1000 Genomes Project Expands with Long-Read Sequencing Data, Enhancing Genetic Variation Insight
The 1000 Genomes Project Long-Read Sequencing Consortium has incorporated PacBio sequencing data to complement existing Oxford Nanopore datasets, aiming for comprehensive telomere-to-telomere...
Sarepta’s Duchenne Gene Therapy Faces Regulatory Roadblocks
Sarepta Therapeutics’ gene therapy Elevidys for Duchenne muscular dystrophy (DMD) has been halted amid growing safety concerns and regulatory setbacks both in the U.S. and Europe. After the FDA...
AI Advances in Protein and RNA Therapeutics
Artificial intelligence continues to revolutionize biotech with significant breakthroughs in protein design and RNA therapy development. Researchers at the University of Washington and Salk...
Breakthroughs in Malaria Control via Mosquito Gene Editing
Innovations in gene editing have yielded a promising new approach to combat malaria transmission. Scientists at UC San Diego and Johns Hopkins University developed a CRISPR-Cas9 allele-drive...
Funding Dynamics in Biotech Amid Market Uncertainties
The biotech sector faces a more cautious investment environment following a period of exuberance during the COVID-19 pandemic. Venture capital is flowing more selectively, favoring companies with...
Advances in Immunotherapy and Oncology Platforms
New immunotherapies and targeted therapies are progressing rapidly through clinical stages and launching innovative platforms. Janux Therapeutics presented promising pipeline data for autoimmune...
Regulatory and Market Developments in Diagnostics and Therapeutics
The FDA granted approval for Geneoscopy’s updated stool collection kit for its ColoSense RNA-based colorectal cancer screening test, designed to improve patient compliance. Roche Diagnostics...
New Therapeutics and Trials in Autoimmune and Inflammatory Diseases
Novel drug candidates and therapies targeting autoimmune and inflammatory conditions advance clinical development. Abivax SA’s obefazimod, a first-in-class miRNA-enhancing oral drug for ulcerative...
Corporate Restructuring and Leadership Changes in Biotech
Several biopharmaceutical companies continue to undergo restructuring to optimize focus amid challenging market conditions. Rocket Pharmaceuticals cut 30% of staff while narrowing its gene therapy...
Research on Human Genomics and Structural Variations
New long-read sequencing studies offer an unprecedented view into human genomic complexity. The University of Washington-led 1000 Genomes Project Long-Read Sequencing Consortium expanded its...
Elevidys Gene Therapy Crisis Hits Duchenne Patients
Sarepta Therapeutics' Duchenne muscular dystrophy gene therapy Elevidys remains embroiled in controversy following its FDA accelerated approval in June 2023. The therapy, priced at $3.2 million,...
Dispatch Bio Launches Universal Solid Tumor Immunotherapy
Dispatch Bio, a biotech startup founded in 2022, officially launched with $216 million in funding, including backing from CAR-T pioneer Carl June. The company’s technology platform, named Flare,...
AI-Designed Protein Binders Enhance Precision Immunotherapy
Researchers led by Nobel Laureate David Baker at the University of Washington have developed artificial intelligence methods to design protein binders targeting peptide-MHC complexes, enabling...
1000 Genomes Project Advances with Long-Read Sequencing Data
The 1000 Genomes Project Long-Read Sequencing Consortium has expanded its efforts by integrating PacBio data alongside nanopore sequencing to generate comprehensive genetic variation maps. This...
Abivax Ulcerative Colitis Drug Surges on Positive Phase 3 Results
Abivax’s experimental miRNA-124 enhancer, obefazimod, demonstrated significant clinical remission and response in two Phase 3 trials for moderately to severely active ulcerative colitis. The 50 mg...