A new open-source tool for automated genomic reanalysis, Talos, helped diagnose rare disease patients by reinterpreting existing genome data with newly discovered gene–variant associations. Researchers at Australia’s Centre for Population Genomics, working with Australian Genomics, the Broad Institute, and Microsoft Research, tested Talos on genomes from 4,735 unsolved cases. The team reported 241 diagnoses, with more than half coming from updates to gene–variant–disease knowledge since initial sequencing. The authors said the software is customizable for different use cases and emphasizes redeployability for other research groups, while clinical labs still manually review positives to maintain specificity. The implication for rare disease programs is less manual, patient-by-patient reanalysis overhead, potentially speeding access to family risk information and trial eligibility.