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High‑throughput chemistry unearths a molecular glue that degrades leukemia driver
A team led by Georg Winter developed a systematic ligand diversification strategy that generated thousands of chemical variants and screened them in living cells to find molecular glues that...
Nature Biotechnology review: engineered cell therapies make clinical headway in autoimmunity
Nature Biotechnology published a review summarizing the latest clinical advances in engineered cellular immunotherapies for autoimmune diseases. Payne and colleagues synthesize emerging trial data...
FDA accepts CSPC’s IND for SYH‑2082 — dual GLP‑1/GIP weight program enters US studies
CSPC Pharmaceutical Group disclosed that the FDA cleared an investigational new drug (IND) application for SYH‑2082, a long‑acting GLP‑1/GIP receptor dual‑biased agonist peptide for weight...
AI‑predicted insulin resistance tied to 12 cancers in UK Biobank analysis
Researchers from the University of Tokyo developed an AI tool (AI‑IR) that predicts insulin resistance from nine routine clinical measures and applied it to 500,000 UK Biobank participants,...
AI tool links insulin resistance to 12 cancers: population-scale finding
Researchers at the University of Tokyo applied a machine‑learning predictor for insulin resistance (AI‑IR) to 500,000 UK Biobank participants and found insulin resistance is a statistically...
Cell‑type gene map for Alzheimer’s reveals causal hub genes – new analysis method
A team at the University of California, Irvine developed SIGNET, a machine‑learning framework that infers cell‑type–specific gene regulatory networks (GRNs) and applied it to Alzheimer’s disease...
High‑throughput chemistry uncovers molecular glue that degrades leukemia driver
Researchers led by Georg Winter and collaborators used a systematic ligand‑diversification strategy combined with live‑cell functional screening to identify new molecular glues that induce...
Fujifilm opens UK single‑use CDMO campus: 19,000 L capacity, £400m investment
Fujifilm Biotechnologies inaugurated an expanded Teesside site in the UK, unveiling what the company calls the largest single‑use biopharmaceutical CDMO facility in the country. Fujifilm Corp....
CBER chief’s conduct and Moderna RTF ignite FDA internal revolt
Reporting by The Wall Street Journal and follow‑up by STAT and Fierce documents internal complaints against Vinay Prasad, head of the FDA’s Center for Biologics Evaluation and Research (CBER), and...
AI hunts antibiotics in genomes and ancient sequences — Penn group scales search
César de la Fuente’s group at the University of Pennsylvania is using artificial intelligence to scour genomes, venoms and ancient sequences for antimicrobial peptides, reporting successive...
Drinkable gene‑therapy foam targets esophageal tumors: noninvasive local delivery
Researchers including Stephan, Cummings and Fitzgerald introduced a novel oral foam formulation intended to deliver gene therapy to constrictive esophageal carcinomas, aiming to overcome access...
Extracellular vesicles rise as nonviral delivery platform for genes and proteins
Researchers outlined strategies to harness extracellular vesicles (EVs) as safer, more precise carriers for gene and protein therapeutics, positioning EVs as an alternative to viral vectors in...
Clinical engineered‑cell therapies for autoimmunity: review flags early wins and gaps
Nature Biotechnology published a review by Payne and colleagues summarizing clinical progress of engineered cellular immunotherapies directed at autoimmune diseases. The review catalogs recent...
New broad‑spectrum prevention method blocks resistant bacteria and influenza
Researchers reported a novel infection‑prevention approach that demonstrated simultaneous blockade of drug‑resistant bacterial pathogens and influenza virus in preclinical tests. The study,...
CBER chief under fire: Moderna flu filing returned after internal pushback
Vinay Prasad, director of the FDA’s Center for Biologics Evaluation and Research (CBER), returned a refusal-to-file (RTF) for Moderna’s mRNA influenza candidate, sparking internal dissent and...
Fujifilm bets £400m: UK site becomes largest single-use CDMO
Fujifilm Biotechnologies opened an expanded Teesside campus in the UK backed by roughly £400 million ($545 million), unveiling what the company calls the UK’s largest single-use biopharma CDMO....
Engineered cell therapies for autoimmunity — Nature Biotechnology outlines clinical advances
Nature Biotechnology published a review summarizing clinical progress for engineered cellular immunotherapies targeting autoimmune diseases. Payne and colleagues synthesize emerging trial data...
Base barrier cells: new brain‑barrier compartmentalization discovered
Researchers reported discovery of specialized 'base barrier cells' that compartmentalize the choroid plexus, brain tissue and cerebrospinal fluid (CSF) in a Nature Neuroscience paper. The study...
Universal AI model raises MRI accuracy: cross‑site brain imaging generalizes
A team led by Tak, Garomsa, and Zapaishchykova published a universal foundation model in Nature Neuroscience that generalizes human brain MRI analysis across sites and protocols. The model...
Tumor microenvironment targeted — ferroptosis nanotherapy rewires CAFs; metabolism drives immunosuppression
Researchers introduced a ferroptosis‑based nanoparticle therapy that reprograms cancer‑associated fibroblasts (CAFs) in colorectal cancer, reversing pro‑tumor stroma phenotypes and sensitizing...