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Two delivery routes advance gene therapy: drinkable foam and extracellular vesicles
Researchers presented a novel oral delivery approach—a drinkable gene‑therapy foam—to target constrictive esophageal carcinoma, aiming to overcome local-access barriers for gene transfer. The...
Regeneration insights: axolotl thymus rebuilds and apple snail regenerates eye
A Science Immunology study shows axolotls can fully regenerate a complex thymus within roughly 35 days, with functional integration after transplantation in follow‑up assays. More than 60% of...
Ultrasound and AI converge: acoustoelectric neural readout and real‑time acoustic trapping
Researchers reported in vivo acoustoelectric neural recording in mice using ultrasound‑induced frequency mixing, demonstrating a minimally invasive route to capture neural signals with spatial...
RNA methylation and neddylation emerge as oncology targets: RCC and CRC mechanisms
A new study shows CDK13 promotes clear cell renal cell carcinoma by enhancing METTL16‑dependent m6A modification of ACLY mRNA, stabilizing and increasing translation of a key metabolic enzyme. The...
CBER head faces internal revolt: Moderna flu filing returned
FDA’s Center for Biologics Evaluation and Research director Vinay Prasad returned Moderna’s mRNA-1010 influenza application and is facing internal complaints alleging interpersonal misconduct and...
Fujifilm doubles UK capacity – £400m CDMO opens
Fujifilm Biotechnologies inaugurated its expanded Teesside, UK campus after a roughly £400 million investment, unveiling what the company says is the largest single-use biopharmaceutical CDMO...
Ultrasound in the clinic: real-time microbubble control and in vivo neural reads
Researchers demonstrated two ultrasound-driven advances that extend acoustic tools into biomedical control and sensing: in vivo acoustoelectric neural recording in mice and AI-guided real-time...
New broad-spectrum defenses: hospital barriers and nicotine‑derived antivirals
Two independent advances target the twin challenges of drug-resistant bacteria and coronaviruses. One team reported a broad-spectrum infection‑prevention approach capable of blocking...
Extracellular vesicles meet ddPCR: precision delivery and measurement for gene therapies
Researchers spotlight extracellular vesicles (EVs) as nonviral vectors for safer, more targeted gene and protein delivery while industry commentary highlights droplet digital PCR (ddPCR) as the...
Universal foundation model advances human brain MRI analysis
A team published a foundation AI model in Nature Neuroscience that generalizes across institutions and scanner types to analyze human brain MRI, offering a scalable framework for cross‑site...
Axolotls regrow thymus: full immune‑organ regeneration observed
Researchers report that axolotls can fully regenerate the thymus, rebuilding the complex organ and restoring function after complete removal, according to a Science Immunology paper. The team...
Oral foam delivers gene therapy to esophageal tumors: a new delivery route
Researchers introduced a drinkable gene‑therapy foam designed to coat and transfect constrictive esophageal carcinoma lesions, presenting a noninvasive route to deliver nucleic acids to...
Next‑gen CCR5 antibody revives immunomodulation strategies
An innovation spotlight detailed a next‑generation CCR5 antagonist antibody, leronlimab, engineered for applications beyond viral entry inhibition, including modulation of tumor microenvironments...
Ferroptosis nanotherapy reprograms colorectal tumor stroma
Researchers unveiled a ferroptosis‑inducing nanotherapy that targets cancer‑associated fibroblasts (CAFs) within colorectal tumors, reversing CAF‑driven fibrosis and restoring a microenvironment...
CBER boss in spotlight: Moderna flu filing returned
The FDA’s Center for Biologics Evaluation and Research (CBER) returned a refusal-to-file (RTF) for Moderna’s influenza vaccine application after CBER director Vinay Prasad overruled internal...
Ultrasound opens acoustoelectric window—first in vivo neural recordings
Researchers have demonstrated in vivo acoustoelectric neural recording in mice by harnessing ultrasound-induced frequency mixing to transduce neural currents into detectable electrical signals....
Universal brain MRI model: AI that generalizes across scanners
A team led by Tak, Garomsa and Zapaishchykova published a foundation AI model in Nature Neuroscience that claims broad generalizability for human brain MRI analysis across cohorts and scanners....
Base barrier cells discovered—new compartmentalizer of choroid plexus
A Nature Neuroscience study identified a specialized population termed “base barrier cells” that compartmentalizes the choroid plexus, brain parenchyma and cerebrospinal fluid (CSF). The paper...
GaAs hybrid-pixel detector enhances 100 keV cryo-EM imaging
Researchers unveiled a gallium arsenide (GaAs) hybrid‑pixel counting detector optimized for 100 keV electron beams that boosts cryo‑EM performance at lower accelerating voltages. The hardware...
Ferroptosis nanotherapy reprograms colorectal cancer fibroblasts
A study led by Wang and colleagues reports a ferroptosis-based nanotherapy that selectively targets colorectal cancer‑associated fibroblasts (CAFs), reversing their tumor-supportive phenotype and...