Researchers introduced a ferroptosis‑based nanoparticle therapy that reprograms cancer‑associated fibroblasts (CAFs) in colorectal cancer, reversing pro‑tumor stroma phenotypes and sensitizing tumors to therapy. The preclinical study reports targeted induction of lipid peroxidation in CAFs to trigger ferroptotic pathways and remodel the tumor microenvironment. Separately, a mechanistic study identified metabolic circuits—nucleotide and lipid pathways—that underpin tumor immunosuppression and T-cell exclusion. Authors describe how altered tumor cell metabolism shapes myeloid and stromal behavior, suggesting metabolic targets to combine with immune-oncology agents. Clarification: Ferroptosis is an iron‑dependent form of regulated cell death driven by lethal lipid peroxidation, distinct from apoptosis.