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AI‑predicted insulin resistance tied to 12 cancers in UK Biobank
Researchers led by Yuta Hiraike at the University of Tokyo applied a machine‑learning tool (AI‑IR) to 500,000 UK Biobank participants and found insulin resistance is a risk factor for 12 cancer...
Systematic ligand diversification finds molecular glue that degrades leukemia driver
Researchers introduced a high‑throughput chemistry-plus‑cellular assay pipeline that diversifies ligands to discover molecular glues capable of inducing target degradation. The team focused on...
New oncology probes: KIF18A and KARS inhibitors enter IP and synthesis reports
Two preclinical programs reported novel inhibitors against cancer targets. Insilico Medicine disclosed KIF18A inhibitors with reported antitumor activity from synthesis and profiling studies....
Regulatory green lights: NMPA OKs Gensci‑136 trials; FDA clears CSPC IND
China’s NMPA authorized Changchun Genescience to begin clinical trials of Gensci‑136, a dual APRIL/BAFF antagonist for immunoglobulin A nephropathy (IgAN). The clearance enables the company to...
FDA rejects Disc’s rare-disease drug — biomarker questions
The FDA has issued a complete response letter to Disc Medicine, rejecting bitopertin for erythropoietic protoporphyria (EPP) and demanding additional clinical data. The agency questioned Disc’s...
FDA leadership clash — former officials and current chiefs at odds
Former FDA oncology chief Richard Pazdur told reporters he resigned after being pressured to endorse reduced clinical-trial requirements, saying he was handed a press release "with a quotation by...
Fujifilm opens UK mega‑CDMO — single‑use capacity expands
Fujifilm Biotechnologies opened an expanded biomanufacturing campus in Teesside, UK, backed by roughly £400 million in investment, creating what the company calls the largest single-use CDMO...
Algorithm assembles human genomes without ultra‑long reads
A team led by Haoyu Cheng at Yale School of Medicine introduced hifiasm (ONT), an algorithm that achieves near end-to-end human genome assembly using standard sequencing inputs, removing the need...
Cell‑type causal map for Alzheimer’s — new GRN method
Researchers at University of California, Irvine developed SIGNET, a machine‑learning framework that infers causal gene regulatory networks (GRNs) across specific brain cell types and used it to...
High‑throughput ligand diversification yields molecular glue for leukemia
A consortium led by Georg Winter’s group reported a high‑throughput chemical diversification strategy that screens thousands of ligand variants in living cells to find molecular glues that induce...
China clears dual APRIL/BAFF candidate for IgA nephropathy trials
Changchun Genescience Pharmaceutical received NMPA clearance to begin clinical trials of Gensci‑136, a dual APRIL/BAFF antagonist formulated for injection to treat immunoglobulin A nephropathy...
FDA accepts IND for CSPC’s GLP‑1/GIP dual agonist for weight management
CSPC Pharmaceutical Group announced that the FDA cleared an investigational new drug (IND) application for SYH‑2082, a long‑acting GLP‑1/GIP dual‑biased agonist peptide for weight management in...
AI links insulin resistance to risk for 12 cancers in 500K cohort
A University of Tokyo team deployed a machine‑learning predictor called AI‑IR to estimate insulin resistance from nine routine clinical measurements across 500,000 UK Biobank participants and...
NYU Langone forecasts autonomous clinical AI within five years
Leaders in health informatics at NYU Langone told reporters they expect fully autonomous clinical AI—algorithms that operate without human oversight for routine tasks—within roughly five years,...
FDA turmoil: Two senior exits and allegations roil agency
Former FDA oncology chief Richard Pazdur says he resigned after being pressured to endorse a policy that reduces clinical trial requirements, alleging he was handed a prewritten quote and told to...
FDA rejects Disc Medicine drug: surrogate endpoint fails to convince
The FDA issued a complete response to Disc Medicine, finding that the surrogate biomarker reduction used in the company’s submission—percent change in whole-blood metal-free PPIX—was not a...
Genome assembly without ultra-long reads: algorithm narrows the gap
Haoyu Cheng at Yale unveiled hifiasm (ONT), an algorithm that assembles near end-to-end human genomes using standard sequencing inputs, eliminating the need for ultra-long DNA reads that demand...
FDA clears IND for CSPC’s GLP-1/GIP candidate for weight management
CSPC Pharmaceutical Group received FDA investigational new drug (IND) clearance for SYH-2082, a long-acting peptide that acts as a GLP-1/GIP dual-biased agonist for weight management in people...
Fujifilm opens UK mega-CDMO: 19,000 L single-use capacity comes online
Fujifilm Biotechnologies inaugurated its expanded Teesside campus in the UK, launching what the company calls the largest single-use CDMO facility in Britain after a roughly £400 million ($545...
AI hunts antibiotics: peptides mined from ancient genomes and venoms
César de la Fuente’s team at the University of Pennsylvania is training machine-learning models to search genomes for novel antimicrobial peptides, uncovering candidates in archaea, animal venoms,...