A team led by Georg Winter developed a systematic ligand diversification strategy that generated thousands of chemical variants and screened them in living cells to find molecular glues that induce degradation of disease proteins. The Nature Chemical Biology paper reports discovery of a compound that selectively degrades ENL, a transcriptional cofactor driving certain acute leukemias, suppressing ENL‑dependent gene programs and leukemia cell growth. The approach couples rapid chemistry with functional cellular assays to accelerate discovery of proximity‑inducing degraders and could expand the tractable target space for targeted protein degradation efforts in oncology.