A study detailed how exosome‑associated long non‑coding RNAs (lncRNAs) modulate tumor behavior across head, neck and thyroid cancers, identifying specific extracellular RNA signatures that influence immune evasion and metastatic potential. Authors propose these exosomal lncRNAs as candidate biomarkers for early detection and as targets to disrupt intercellular tumor communication. Exosomes are small extracellular vesicles that carry RNA and protein cargo between cells; lncRNAs are regulatory RNA molecules that do not code for protein but can alter gene expression. The work suggests translational opportunities for liquid biopsies and targeted anti‑exosome strategies.