A 2026 study demonstrated that simultaneous inhibition of IGF‑1 receptor signaling and autophagy suppresses colorectal cancer metastasis in preclinical models. Mahgoub and colleagues showed the combination impaired tumor cell survival mechanisms and reduced metastatic outgrowth compared with single‑pathway inhibition. The findings propose a mechanistic rationale for clinical combinations that target both growth‑factor signaling and cellular recycling pathways. Clarification: autophagy is a cellular process that degrades and recycles intracellular components; inhibiting it can sensitize tumors to other targeted therapies.