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Positive colorectal data sends CytomX shares on a rollercoaster
CytomX reported positive dose‑expansion data from a Phase I trial of varsetatug masetecan (varseta‑M) in metastatic colorectal cancer, prompting sharp intraday stock moves. At the 10 mg/kg dose...
Alectinib boosts CAR T efficacy in ALK‑driven neuroblastoma models
Preclinical work shows the ALK inhibitor alectinib can enhance CAR T‑cell cytotoxicity against ALK‑driven neuroblastoma, researchers report. The study details combination experiments where...
UK trial finds no extra benefit from surfactant in severe infant bronchiolitis
A UK‑led randomized clinical trial concluded that surfactant therapy provided no additional clinical advantage for infants with severe bronchiolitis who required mechanical ventilation....
Nearly one‑in‑five pediatric hospital deaths linked to sepsis — JAMA study
A national study published in JAMA estimated that nearly 20% of pediatric hospital deaths in the U.S. are associated with sepsis, providing the first standardized assessment of pediatric sepsis...
Reinforced biotubes offer off‑the‑shelf vascular graft alternative
Researchers published Nature Communications results describing reinforced biotubes as a regenerative vascular graft option designed for ready availability. The team, led by Cheng, Zhi, and...
HKUST reveals DICER’s single‑nucleotide precision in microRNA processing
A team at The Hong Kong University of Science and Technology delineated how the human enzyme DICER achieves single‑nucleotide precision when processing microRNAs, advancing mechanistic...
Acinetobacter capsule structure drives resistance and immune evasion
Researchers reported that structural variations in Acinetobacter capsules modulate both antibiotic resistance and host immune responses, shedding light on pathogenicity mechanisms of A. baumannii....
Blood–brain barrier remains leaky years after contact sports — long‑term risk signal
A study in Science Translational Medicine found that retired contact‑sport athletes showed persistent blood–brain barrier leakiness years after play, and that barrier disruption correlated with...
Novartis agrees up to $3B for Pikavation – adds mutant‑selective PI3Kα
Novartis struck a deal to acquire Pikavation for up to $3 billion, paying roughly two‑thirds up front to add SNV4818, a mutant‑selective PI3Kα inhibitor, to its oncology portfolio. Pikavation is a...
CytomX’s ADC posts 32% ORR in mCRC... Stock whipsaws after data
CytomX reported positive dose‑expansion Phase I data for varsetatug masetecan (varseta‑M) in metastatic colorectal cancer, showing a 32% overall response rate and median progression‑free survival...
AI fuels N‑of‑1 medicine... Bespoke therapies move from idea to pilots
Researchers and industry leaders at the 2026 Precision Medicine World Conference argued that AI, advanced protein‑folding models, and high‑frequency personal data are enabling ‘N‑of‑1’...
World’s brightest X‑rays map intact organs: New open‑access organ atlas
Researchers used the world’s brightest X‑ray sources to image intact human organs at unprecedented resolution and launched an open‑access portal to explore the datasets. The project provides...
Cellares: Automation, closed systems and networks to scale cell therapy
Cellares argued that automation, closed manufacturing systems, and global production networks are the path to making cell therapy a broadly accessible medicine. Fabian Gerlinghaus outlined...
How DICER cuts microRNAs: Single‑nucleotide precision revealed
A team at HKUST unveiled the molecular mechanism by which human DICER processes precursor microRNAs with single‑nucleotide precision. The study mapped structural features and catalytic steps that...
Acinetobacter capsules reshape antibiotic resistance and immune evasion
Researchers reported that structural variations in Acinetobacter capsules influence both antibiotic resistance and host immune recognition. The study dissected how capsule composition alters drug...
New live‑attenuated VEE vaccines advance as outbreak countermeasure
Researchers developed novel live‑attenuated vaccine candidates for Venezuelan equine encephalitis virus (VEEV) to address a persistent arboviral threat lacking a broadly licensed human vaccine....
Utah pilots AI refill bot: Researchers flag security and safety gaps
Utah began piloting an autonomous prescription‑refill chatbot developed by Doctronic to streamline routine renewals and improve adherence. A Mindgard AI report, however, identified vulnerabilities...
GlassWorm hides malware in invisible text... Open‑source supply chain at risk
Security researchers uncovered a campaign dubbed GlassWorm that embeds malicious payloads in open‑source contributions using invisible Unicode characters. Attackers submitted seemingly benign code...
Novartis pays up to $3B for Pikavation – adds PI3Kα mutant‑selective asset
Novartis agreed to acquire Pikavation Therapeutics for up to $3 billion to add SNV4818, a mutant‑selective PI3Kα inhibitor, to its oncology pipeline. The deal includes a multi‑hundred‑million...
Study: sepsis tied to nearly 20% of US pediatric hospital deaths
A national analysis published in JAMA quantified pediatric sepsis burden and found sepsis implicated in nearly one in five pediatric hospital deaths across the United States. The study provided...