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Roche, Zealand: Obesity peptide meets Phase 2 goals – weight loss under expectations
Roche and Zealand Pharma reported that petrelintide, a peptide amylin-receptor agonist, met the primary endpoints in a Phase 2 obesity study with tolerability comparable to placebo. The trial...
Lenacapavir resistance pathways mapped: HIV finds new escape routes
Researchers published a Nature Communications study mapping recurrent and novel HIV-1 evolutionary pathways that confer resistance to lenacapavir, the long-acting capsid inhibitor. The team, led...
Dilution-and-delay assay... High-throughput detection exposes hidden antibiotic resistance
A Nature Communications paper from Ma and Kim introduces the dilution-and-delay (DnD) susceptibility assay, a high-resolution, high-throughput method designed to detect low-frequency or inducible...
ITK targeting... Rewiring T cells to boost anti‑CD19 CAR‑T potency
Researchers reported that inhibition or genetic targeting of interleukin-2–inducible T-cell kinase (ITK) improves the potency and persistence of anti-CD19 CAR‑T cells in preclinical models. The...
DNA repair mutations reshape PDAC chemo response — biomarker implications
A new study shows that tumor-intrinsic DNA repair gene alterations modulate response to combination chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC). Investigators analyzed...
AI mines mammograms: routine screens flag future heart disease risk
A study in the European Heart Journal adapted AI to quantify breast arterial calcification (BAC) on routine mammograms and demonstrated that BAC measurements predict cardiovascular disease risk,...
World’s tiniest robot... sub‑millimeter machines promise biomedical applications
University of Pennsylvania researchers built a sub-millimeter robot with onboard sensors, an actuator, and a microcontroller; the devices are solar-powered, can move through fluids via...
The age of animal experiments may be waning: NAMs scale up
Policy moves from the UK, the U.S. FDA and the NIH, alongside major investments in China, are accelerating a shift away from traditional animal testing toward new-approach methodologies (NAMs)...
Vinay Prasad to depart FDA again — agency leadership shift in April
Vinay Prasad, director of the FDA’s Center for Biologics Evaluation and Research (CBER), will leave the agency at the end of April, marking a second exit amid a string of high-profile regulatory...
Daraxonrasib posts strong responses — Phase 3 push in RAS-mutant pancreatic cancer
Revolution Medicines reported daraxonrasib (RMC-6236) produced substantial objective responses in RAS-mutant metastatic pancreatic ductal adenocarcinoma (PDAC), prompting plans toward a Phase 3...
Roche–Zealand peptide meets endpoints — obesity readout shows tolerability, modest weight loss
Zealand Pharma and Roche reported Phase 2 results for petrelintide, an amylin-receptor–targeting peptide, showing tolerability comparable to placebo but average weight loss below some analyst...
New high-throughput DnD assay finds hidden antibiotic resistances — diagnostic advance
Researchers Ma and Kim published a dilution‑and‑delay (DnD) susceptibility assay in Nature Communications that detects previously hidden antibiotic resistance phenotypes at high resolution and...
Study maps new HIV‑1 lenacapavir resistance paths — implications for long‑acting therapy
A Nature Communications study by Orris, Siddiqui, Tang and colleagues delineated recurrent and novel evolutionary routes HIV‑1 takes to escape lenacapavir, a long‑acting capsid inhibitor used in...
Targeting ITK enhances anti‑CD19 CAR‑T potency — preclinical route to better cell therapies
Researchers reported that inhibiting ITK (interleukin‑2‑inducible T‑cell kinase) can remodel CAR‑T cells to improve anti‑CD19 therapeutic activity in preclinical models. The strategy altered...
Low‑cost sample hashing scales single‑cell multiomics — clinical sample workflows advance
A new workflow built around Seq‑Well enables scalable, low‑cost sample hashing for single‑cell multiomics, improving throughput for precious clinical samples. The method streamlines barcoding and...
Penn unveils sub‑millimeter robots with sensors and onboard compute — medical microrobotics step
Researchers at the University of Pennsylvania led by Marc Miskin introduced sub‑millimeter robots equipped with sensors, a motor, onboard computation and tiny solar cells to power movement and...
Phase III ACWY‑TT vaccine shows safety and efficacy in toddlers — pediatric meningococcal option advances
A Phase III trial of a quadrivalent meningococcal ACWY‑TT conjugate vaccine in infants aged 6 to 23 months conducted in the U.S. and Puerto Rico demonstrated favorable immunogenicity and safety,...
ESC issues patient‑facing pregnancy CVD guidance — shared decision tools released
The European Society of Cardiology published a patient‑focused version of its guidelines addressing cardiovascular disease management during pregnancy, released on International Women’s Day. The...
Servier boosts rare-cancer push: $2.5B Day One buyout
Servier agreed to acquire Day One Biopharmaceuticals for about $2.5 billion, adding the FDA‑approved pediatric glioma drug Ojemda and an early-to-late stage oncology pipeline to its portfolio. The...
Vinay Prasad to depart FDA again — exit set for end of April
Vinay Prasad, director of the FDA’s Center for Biologics Evaluation and Research, will leave the agency at the end of April after a turbulent tenure marked by high‑profile rejections and reversals...