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Ionis Pharmaceuticals’ Olezarsen Slashes Triglycerides and Pancreatitis Risk in Pivotal Trials
Ionis Pharmaceuticals announced positive topline results from pivotal Phase 3 CORE and CORE2 studies demonstrating the efficacy of olezarsen in severe hypertriglyceridemia (sHTG). The therapy...
Strategic Acquisition: SeqOne Merges With Congenica to Enhance Genomic Diagnostics
French genomics software company SeqOne has acquired UK-based Congenica, combining SeqOne's AI-powered next-generation sequencing platform with Congenica's clinical decision support and genome...
Merck Advances Oral PCSK9 Inhibitor, Prepares Regulatory Discussions After Phase 3 Success
Merck & Co. announced a third consecutive phase 3 study win for its oral PCSK9 inhibitor, advancing its CORALreef program for hyperlipidemia treatment. With positive clinical results in broader...
John Maraganore and Clive Meanwell Launch Corsera Health to Combat Cardiovascular Disease
Veteran biotech leaders John Maraganore and Clive Meanwell launched Corsera Health with a mission to prevent cardiovascular disease using a combination of AI-based risk prediction and RNA...
FDA Approves Injectable Alzheimer’s Drug Leqembi for Home Maintenance Dosing
The FDA has approved Leqembi, an injectable form of Eisai and Biogen’s Alzheimer’s drug, permitting weekly maintenance dosing that can be administered at patients’ homes. This regulatory milestone...
Foresight Diagnostics and Roche Settle Patent Dispute With Licensing Agreement
Foresight Diagnostics and Roche Molecular Systems have resolved ongoing litigation related to PhasED-Seq sequencing technology through a limited licensing agreement. The deal grants Roche a...
New FDA Clearance for Qiagen’s High-Throughput Syndromic Testing System QIAstat-DX Rise
Qiagen received FDA 510(k) clearance for the QIAstat-DX Rise Syndromic Testing System, capable of processing up to 160 samples daily with automation features including cartridge loading/unloading...
Advanced Deep Learning Model Pythia Enables Precise Genome Editing Across Cell Types
Researchers have introduced Pythia, a deep learning framework improving the precision of CRISPR–Cas9-mediated genome engineering. Pythia predicts optimal repair templates, enabling more accurate...
Tryngolza Shows Promise in Severe Triglyceride Disease With Significant Clinical Benefit
Ionis Pharmaceuticals announced compelling late-stage data for Tryngolza, an RNA-targeting therapy, which significantly reduced triglyceride levels and acute pancreatitis incidences in patients...
New Noninvasive Colorectal Cancer Test ColoAlert Cleared for UK Market
Mainz Biomed secured UK Medicines and Healthcare Products Regulatory Agency approval for ColoAlert, a PCR-based stool DNA biomarker test for colorectal cancer detection. Following its Swiss...
AI Enhances Naloxone Co-prescribing to Tackle Opioid Crisis
Amid the escalating opioid epidemic, healthcare providers are adopting artificial intelligence-based clinical decision support systems to improve naloxone co-prescribing in hospitals. This...
New Alzheimer’s Drug Leqembi Gains FDA Approval for Home Use
The FDA has approved an injectable formulation of Leqembi, developed by Eisai and Biogen, facilitating weekly maintenance dosing that can be administered in patients' homes. This approval marks a...
Lilly Narrows Oral GLP-1 Trials, Focuses on Key Program After Mid-Stage Cuts
Eli Lilly has discontinued two of three mid-stage clinical trials of its oral GLP-1 diabetes drug candidate naperiglipron citing strategic business reasons. The remaining phase 2 trial targets...
Royalty Pharma Secures $950 Million Deal for Amgen’s Lung Cancer Immunotherapy
Royalty Pharma has acquired royalty interests in Amgen’s Imdelltra (tarlatamab-dlle), an FDA-accelerated bispecific T-cell engager approved for extensive-stage small cell lung cancer. The $950...
AI Detects Covert Consciousness in Comatose Patients via Facial Microexpressions
Researchers developed an AI-enabled system named SeeMe that analyzes subtle facial muscle movements in comatose brain injury patients to detect consciousness unperceivable by standard clinical...
Novel Antimicrobial Compounds Discovered in Venoms Using Artificial Intelligence
Researchers applied AI algorithms to analyze venom proteomes from snakes, spiders, and scorpions, uncovering new potent antimicrobial peptides with rapid and specific antibacterial effects. This...
CRISPR Editing Efficiency Tripled by DNA-Wrapped Nanoparticles
Scientists have enhanced CRISPR-Cas9 genome editing precision and efficiency by developing DNA-wrapped nanoparticle delivery platforms that increase targeted DNA integration rates in diverse cell...
Sino Biological’s One-Stop Solutions Streamline CAR T-cell Therapy Development
With CAR T-cell therapies becoming mainstream in oncology and autoimmune diseases, Sino Biological offers an integrated platform of validated bioreagents supporting all phases of CAR T-cell...
Teva Scores FDA Nod for First Generic Weight Loss GLP-1 Drug
Teva Pharmaceuticals has secured FDA approval for a generic version of liraglutide, the first generic glucagon-like peptide-1 (GLP-1) agonist indicated for adult and adolescent weight management....
MRI Radiomics Correlates with Tumor Microenvironment in Cervical Cancer
A multidisciplinary research team has demonstrated significant associations between advanced MRI radiomic features and the biological characteristics of cervical cancer tumor microenvironments. By...