Researchers introduced GRAPE‑LM, a method that enables single‑round directed evolution of RNA aptamers, streamlining what traditionally required multiple cycles of mutation and selection. The report described how GRAPE‑LM couples model‑guided library design with high‑throughput screening to produce functional aptamers rapidly. The technique shortens development timelines for therapeutic and diagnostic aptamers and may reduce resource intensity for early‑stage molecular engineering. Authors noted the potential to integrate GRAPE‑LM with other computational selection tools to expand target scope. For biotech teams working on nucleic‑acid therapeutics, GRAPE‑LM represents a practical advance in selection efficiency and could accelerate lead discovery for aptamer‑based drugs and sensors.