Researchers published mechanistic data showing focused ultrasound transiently and reversibly opens the blood–brain barrier by reorganizing tight junction proteins. The study, in Communications Engineering, mapped structural rearrangements that permit targeted permeability without long‑term junction loss. Authors reported that the opening is localized and self‑resolving, controlled by acoustic parameters and microbubble interactions. The paper provides molecular‑level evidence supporting clinical focused‑ultrasound approaches for CNS drug delivery and antibody penetration. The findings deliver a technical clarification for developers planning intraparenchymal or systemic delivery of biologics: ultrasound parameters can be tuned to create transient tight‑junction remodeling rather than broad barrier compromise.