A multi‑ancestry genome‑wide association study led by Shi, He, Li, and colleagues identified 140 genetic loci associated with age‑related hearing loss and published the results in Nature Communications. The analysis pooled diverse populations to improve variant discovery and biological interpretation for ARHL. The loci map to pathways involved in inner‑ear function and neural processing, offering new targets for therapeutic development and genetic risk stratification. Pharmaceutical and genetic‑therapy developers may use the findings to prioritize targets for hearing‑restorative interventions.