Two complementary reports show that internally disordered lipid nanoparticles (LNPs) can deliver RNA cargo more efficiently than highly ordered particles. University of Copenhagen researchers presented single‑particle, high‑throughput measurements revealing two LNP subpopulations—organized and amorphous—and found that the amorphous particles released cargo more effectively inside cells. The findings challenge the prevailing strategy of maximizing payload packing and suggest formulation tactics that favor partial internal disorder to boost endosomal escape and functional delivery. Drug developers working on mRNA vaccines, cancer therapies, and rare‑disease RNA treatments may reassess LNP manufacturing and analytical QC to enrich for the higher‑performing subpopulation.