Researchers unveiled a gallium arsenide (GaAs) hybrid‑pixel counting detector optimized for 100 keV electron beams that boosts cryo‑EM performance at lower accelerating voltages. The hardware advance improves signal detection and could expand high-resolution imaging of radiation-sensitive biological specimens while lowering sample damage. By enabling more efficient counting at 100 keV, the detector may democratize structural work that previously required higher-energy microscopes, accelerating structure-based drug discovery and structural virology in labs without 300 keV platforms.