Researchers have demonstrated in vivo acoustoelectric neural recording in mice by harnessing ultrasound-induced frequency mixing to transduce neural currents into detectable electrical signals. The team reports the method provides spatially specific neural readouts with minimal invasiveness, positioning acoustoelectric approaches as a new interface for neurophysiology and brain‑machine interfacing experiments. The work, performed in preclinical models, shows feasibility but will require validation of signal fidelity, biocompatibility and translation to larger brains. If scalable, the technique could complement optical and electrode-based recordings for both basic neuroscience and neural prosthetic development.