A multi‑center genetics study identified germline DNA repair deficiencies as a driver of early‑onset gastrointestinal cancers, linking inherited repair pathway defects to earlier presentation and distinct tumor biology. The research, led by Wang Yang and colleagues, mapped germline variants in DNA‑repair genes and correlated them with cancer phenotypes and age of onset. Findings support expanded genetic testing in younger GI cancer patients and suggest opportunities for targeted surveillance and precision therapy selection. Clinical groups and genetic counselors will need to consider broader testing thresholds and follow‑up strategies for at‑risk families.