Two independent multi‑omics reports traced immune responses after a genetically modified pig kidney was transplanted into a brain‑dead human recipient and maintained for 61 days. Teams collected serial tissue, blood and fluid samples and used single‑cell and bulk omics to map antibody‑ and T‑cell‑driven mechanisms of rejection, then demonstrated reversal of rejection with approved drug combinations. Authors reported that antibody plus T‑cell activity drove graft injury but that targeted immunomodulation could restore graft function without permanent damage. The studies provide day‑by‑day mechanistic insight useful for designing immunosuppression regimens and for planning controlled trials of porcine xenotransplants in living recipients.