St. Jude Children’s Research Hospital and the National Cancer Institute published the first and largest pediatric cancer structural‑variant (SV) dataset in Cancer Cell, offering a pan‑cancer map of genomic rearrangements that drive childhood tumorigenesis. The resource catalogs SVs across multiple pediatric tumor types, annotates recurrent events, and links structural changes to disrupted genes and potential therapeutic targets. Authors highlighted novel SV classes and chromothripsis‑like events that disproportionately contribute to oncogenic driver formation in children. The dataset is intended to accelerate target discovery, refine diagnostic genomics, and support rare‑tumor trial design by providing prevalence and mechanistic context for tumor‑specific structural lesions.